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Metabolism of 2,3-Diphosphoglycerate in Red Blood Cells under Various Experimental Conditions

  • E. Gerlach
  • J. Duhm
  • B. Deuticke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)

Abstract

It took about forty years after GREENWALD discovered in 1925 (1) 2,3-diphosphoglycerate (2,3-DPG) to be a major constituent of red blood cells (RBC) before the first reports were published concerning the functional significance of this compound. While CHANUTIN and CURNISH detected the binding of 2,3-DPG to hemoglobin (2), BENESCH and BENESCH (3) as well as CHANUTIN (4) almost simultaneously demonstrated the effects of this binding on the oxygen affinity of hemoglobin.

Keywords

Sulfur Compound Blood Hemoglobin Glycolytic Intermediate Oxygen Dissociation Curve Inorganic Sulfur Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • E. Gerlach
    • 1
  • J. Duhm
    • 1
  • B. Deuticke
    • 1
  1. 1.Department of PhysiologyMedical Faculty Technical UniversityAachenGermany

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