Binding of Organic Phosphates to Hemoglobin A and Hemoglobin F

  • Lars Garby
  • Carl-Henric de Verdier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 6)


A new physiological system for the regulation of the oxygen affinity to hemoglobin has been discovered during the last two years. Addition of 2,3-diphosphoglycerate (DPG) and adenosine triphosphate (ATP) to dilute hemoglobin solutions dramatically decreased the affinity of the hemoglobin for oxygen (Benesch & Benesch, 1967; Chanutin and Curnish, 1967) and a close inverse relation was found (Akerblom et al., 1968; Engel & Duc, 1968; Lenfant et al., 1968) between the oxygen affinity and the concentration of these phosphocompounds in intact human erythrocytes.


Association Constant Adenosine Triphosphate Oxygen Affinity Organic Phosphate Hemoglobin Solution 


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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Lars Garby
    • 1
  • Carl-Henric de Verdier
    • 1
  1. 1.Department of Clinical Physiology and Department of Clinical ChemistryUniversity HospitalUppsalaSweden

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