Binding of Organic Phosphates to Hemoglobin A and Hemoglobin F
A new physiological system for the regulation of the oxygen affinity to hemoglobin has been discovered during the last two years. Addition of 2,3-diphosphoglycerate (DPG) and adenosine triphosphate (ATP) to dilute hemoglobin solutions dramatically decreased the affinity of the hemoglobin for oxygen (Benesch & Benesch, 1967; Chanutin and Curnish, 1967) and a close inverse relation was found (Akerblom et al., 1968; Engel & Duc, 1968; Lenfant et al., 1968) between the oxygen affinity and the concentration of these phosphocompounds in intact human erythrocytes.
KeywordsAssociation Constant Adenosine Triphosphate Oxygen Affinity Organic Phosphate Hemoglobin Solution
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