Cytophotometric and Autoradiographic Investigations on Germinal Center Cells in Man

  • K. Lennert
  • P. Mitrou
  • H. K. Muller-Hermelink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


By employing hematologic techniques, several cell types can be regularly identified in human germinal centers. We have called them germinocytes and germinoblasts [1, 2, 3]. However, to us it does not make any difference which terms are being used with respect to those cells. We just want to make it clearly understood that those characteristic cells can be always identified in human germinal centers by means of hematologic techniques, lie presented the electron microscopic criteria of those cells at the last germinal center conference [4]. Now we should like to give an excerpt from our quantitative cytochemical investigations of the nuclei of those cells. In previous investigations [5, 6, 7], we determined the amount of DNA, nuclear total protein, and histone protein of lymphocytes, germinocytes, germinoblasts, immunoblasts, and plasma cell precursors in germinal centers. This was done successively on the same cell by cytophotometry.


Germinal Center Label Intensity Germinal Center Cell Autoradiographic Investigation High Incorporation Rate 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • K. Lennert
    • 1
  • P. Mitrou
    • 1
  • H. K. Muller-Hermelink
    • 1
  1. 1.Department of PathologyUniversity of KielKielGermany

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