Immunoglobulin-Producing Cells in Human Pericancerous Lymph Nodes
One of the great problems in cancerology is whether an immunological defense against cancer exists and develops in the human body. Among the places where this defense could be situated would be the regional lymph nodes, which could receive the eventual tumor antigens in a soluble form through the lymph ducts and also enter into direct contact with them when a metastasis occurs in the lymph nodes. within these lymph nodes several defense mechanisms might be triggered off: phagocytosis, production of antibodies against the cancerous antigens, or an attack on the cancerous cells by the lymphoid cells sensitized against these antigens. It is impossible to judge the production of antibodies directly because we do not know the antigens to which they would react. However, we can estimate it indirectly by a study of the presence of immunoglobulins in pericancerous lymph nodes, as compared with lymph nodes taken from cancer-free subjects. That is what we have done, using the method of direct immunofluorescence. We have thus been able to determine the number and type of the immunoglobulin- producing cells according to the histological structure of the lymph nodes and to establish the relative production of the various immunoglobulins.
KeywordsLymph Node Primary Biliary Cirrhosis Lymphoid Cell Germinal Center Lymphoid Follicle
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