Thymic Germinal Centers as Foci of a Lymphoma Resembling Burkitt’s Tumor

  • C. Jerusalem
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


In a previous communication the appearance of an aleukemic malignant lymphoma resembling Burkitt’s tumor in Swiss mice was described [1]. The lymphoma was observed much more frequently in mice immune toPlasmodium berghei than in controls of the same age. By electron microscopy, virus particles could be shown in the germinal centers of the splenic lymphatic nodules during the very early stages of malignant growth. The thymus was seen to be even more involved than the spleen (64% as opposed to 44%). Since in most instances the thymus shows distinct changes during primary infection [2, 3], the question arises as to whether the thymus can be regarded as a focus of tumor development.


Virus Particle Germinal Center Reticular Cell Swiss Mouse Small Lymphocyte 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • C. Jerusalem
    • 1
  1. 1.Laboratory of Cytology and HistologyUniversity of NijmegenNijmegenThe Netherlands

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