Thymic Germinal Centers as Foci of a Lymphoma Resembling Burkitt’s Tumor

  • C. Jerusalem
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


In a previous communication the appearance of an aleukemic malignant lymphoma resembling Burkitt’s tumor in Swiss mice was described [1]. The lymphoma was observed much more frequently in mice immune toPlasmodium berghei than in controls of the same age. By electron microscopy, virus particles could be shown in the germinal centers of the splenic lymphatic nodules during the very early stages of malignant growth. The thymus was seen to be even more involved than the spleen (64% as opposed to 44%). Since in most instances the thymus shows distinct changes during primary infection [2, 3], the question arises as to whether the thymus can be regarded as a focus of tumor development.


Virus Particle Germinal Center Reticular Cell Swiss Mouse Small Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    C. Jerusalem, Z. Tropenmed. Parasitol., 19:94, 1968.PubMedGoogle Scholar
  2. 2.
    C. Jerusalem, Ann. Soc. Beige Med. Trop., 45:405, 1965.Google Scholar
  3. 3.
    W. Eling and C. Jerusalem, Anat. Anz., 121:197, 1968.Google Scholar
  4. 4.
    E. R. Fisher, in: R. A. Good and Ann E. Gabrielsen, Eds., The Thymus in Immunobiology, p. 676. New York-Evanston-London: Harper and Row, 1964.Google Scholar
  5. 5.
    D. Metcalf, The Thymus: Its Role in Immune Response, Leukemia Development and Carcinogenesis. Berlin-Heidelberg-New York: Springer-Verlag, 1966.Google Scholar
  6. 6.
    U. Bernhard, in: A. V. S. Reuck and J. Knight, Eds., Cellular Injury, p. 209. London: J. h A. Churchill, 1964.Google Scholar
  7. 7.
    W. Kretschmar and C. Jerusalem, Z. Tropenmed. Parasitol., 14:279, 1963.Google Scholar
  8. 8.
    C. Jerusalem, Z. Tropenmed. Parasitol., 15:371, 1964.Google Scholar
  9. 9.
    E. De Harven, Discussion on paper by Furth et al., in: R. A. Good and Ann E. Gabrielsen, Eds., The Thymus in Immunobiology, p. 621. New York-Evanston-London: Harper and Row, 1964.Google Scholar
  10. 10.
    D. W. van Bekkum, in: Biotechnisch Symposium L.W.L., pp. 7–12. Utrecht: Transitorium, 1965.Google Scholar
  11. 11.
    C. Jerusalem and Ute Heinen, Anat. Anz., 120:157, 1967.Google Scholar
  12. 12.
    D. P. Burkitt, 9th Ann. Meeting Brit. Ass. Cane. Res., London, 1968.Google Scholar
  13. 13.
    L. Dmochowski, C. E. Grey, and L. Gross, in: Radiation Biology and Cancer, Symposium on Fundamental Cancer Research, p. 382. University of Texas Press, 1958.Google Scholar
  14. 14.
    I. Furth, H. Okano, and A. Kunil, in: R. A. Good and Ann E. Gabrielsen, Eds., The Thymus in Immunobiology, p. 595. New York-Evanston-London: Harper and Row, 1964.Google Scholar
  15. 15.
    G. J. V. Nossal, Ann. N. Y. Acad. Sci., 120:170, 1964.Google Scholar
  16. 16.
    J. F. A. P. Miller, Brit. Med. Bull., 21:111, 1965.PubMedGoogle Scholar
  17. 17.
    M. Galton and Penelope B. Reed, Transplantation, 4:168, 1966.CrossRefGoogle Scholar
  18. 18.
    L. Dmochowski, F. Padgett, and L. Gross, Cancer Res., 24:869, 1964.PubMedGoogle Scholar
  19. 19.
    E. A. Gall and H. Rappaport, in: Proceedings of the Twenty- third Seminar of the American Society of Clinical Pathologists, October 4, 1957.Google Scholar
  20. 20.
    G. T. O’Conor, Cancer Philad., 14:270, 1961.CrossRefGoogle Scholar
  21. 21.
    G. T. O’Conor, H. Rappaport, and E. B. Smith, Cancer Philad. 18:411, 1965.CrossRefGoogle Scholar
  22. 22.
    G. J. V. Swaen, J. Natl. Cancer Inst., 36:1027, 1966.PubMedGoogle Scholar
  23. 23.
    E. De Harven, in: A. J. Dalton and F. Haguenau, Eds., Tumors Induced by Viruses: U1trastructural Studies, p. 183. New York and London: Academic Press, 1962.Google Scholar
  24. 24.
    L. Dmochowski, in: F. O. J. Hayhoe, Ed., Current Research in Leukemia. Cambridge: University Press, 1965. 111.4Google Scholar
  25. 25.
    J. J. Butler, A. Szakas, and J. G. Sincovics, Am. J. Pathol., 51:629, 1967.PubMedGoogle Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • C. Jerusalem
    • 1
  1. 1.Laboratory of Cytology and HistologyUniversity of NijmegenNijmegenThe Netherlands

Personalised recommendations