Immunoglobulins in Pregnancy and Malignant Trophoblastic Disease
In work presented at the first germinal center conference, we showed that pregnancy and malignant trophoblastic disease are associated with disappearance of germinal centers from lymph nodes [1, 2]. These findings were discussed in relation to other changes known to occur in the thymus and lymphatic tissue during pregnancy in small mamnals: a reversible atrophy of the thymus [3, 4], reduction in size of lymph nodes as well as a marked reduction in the number of small lymphocytes in lymph nodes, and an absolute lymphopenia in peripheral blood . We also noted the lympholytic effects of adrenal steroids and the thymolytic effect of estrogen and the adrenal steroids [6, 7] and emphasized that these hormones are produced in increased amounts in pregnancy. We pointed out that the foregoing suggests an inhibitory effect of pregnancy on the thymus and lymphatic tissue; the inhibitory effect seemed to be more profound in cases of malignant trophoblastic disease.
KeywordsNegro Woman Germinal Center Absolute Lymphocyte Count Adrenal Steroid Hydatidiform Mole
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