Germinal Centers, Hassall’s Corpuscles, and Epithelioid Granulation Tissue

  • C. C. Congdon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


The germinal centers of lymphatic tissue, the Hassall’s corpuscle of the thymus, and the tubercle of epithelioid granulation tissue are three unique histologic entities that may have a common biological significance. All three structures morphologically show a superficial similarity, and we sometimes refer to atrophic germinal centers depleted of their parenchymal cells as pseudotubercles or pseudo-Hassall’s corpuscles [1, 2]. Separating the structures from the point of view of diagnostic pathology has not been a major issue [2]. Shared functional properties, however, would be of considerable interest and would explain the anatomical similarity.


Germinal Center Epithelioid Cell Stromal Compartment Lepromatous Leprosy Superficial Similarity 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • C. C. Congdon
    • 1
    • 2
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA
  2. 2.Department of Zoology and EntomologyUniversity of TennesseeKnoxvilleUSA

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