Advertisement

Lymphatic Follicles and Immunologic Cell Reaction in Human Jejunal Mucosa Obtained by Peroral Biopsy in Infectious Hepatitis

  • G. Astaldi
  • R. Airo
  • M. E. Conrad
  • R. Penna
  • F. Ceretto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)

Abstract

The concept that the lymphoid tissue of the gastrointestinal tract is primarily involved in the immune defense mechanism has been repeatedly maintained by several investigators [1, 2]. Activation of intestinal lymphocytes to large pyroninophilic cells has been observed in cases where the lymphocytes, after crossing the basement membrane, have penetrated between or into the cells of the covering epithelium of intestinal villi [3, 4, 5, 6]. Such lymphatic transformation has been interpreted as an immunological reaction, but the most overwhelming evidence of the immunological function of the intestinal lymphoid tissue was provided by studies of Good and co-workers [7, 8, 9, 10], showing that the Peyer’s-patch-type of intestinal lymphoid tissue represents the mammalian counterpart of the bursa Fabricii in birds. On the other hand, it has been shown that the plasma cells of the intestinal mucosa constitute the major source of gamma-A immunoglobulins [11] and that gamma-A and gamma-M immunoglobulins are significantly increased in infectious hepatitis [12], which has been considered a generalized disease [13, 14]. Because the jejunal mucosa in infectious hepatitis occasionally shows a partial villous atrophy and frequently shows a marked cellular infiltration within the tunica propria [15], we undertook the present investigation. This study was performed to ascertain whether the intestinal infiltration contains immunologically activated cells, to determine the quantity of these cells, and to investigate the behavior of the lymphatic follicles and germinal centers of the duodenojejunal mucosa during the course of infectious hepatitis. These findings could be related to recent concepts of the immunological function of the lymphoid tissue in gastrointestinal tract.

Keywords

Plasma Cell Germinal Center Infectious Hepatitis Cellular Infiltration Jejunal Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    C. K. Drinker and J. M. Yoffey, Lymphatics, Lymph and Lymphoid Tissue. Their Physiological and Clinical Significance. Cambridge: Harvard University Press, 1941.Google Scholar
  2. 2.
    M. A. Kelsall and E. D. Crabb, Lymphocytes and Mast Cells, p. 272. Baltimore: Williams and Wilkins Co., 1959.Google Scholar
  3. 3.
    G. Astaldi and E. Strosselli, Gazz. Intern. Med. Chir., 64:857, 1959.Google Scholar
  4. 4.
    W. Andrew, J. Natl. Cancer Inst., 35:113, 1965.PubMedGoogle Scholar
  5. 5.
    G. Astaldi, R. Penna, and F. Ceretto, Minerva Med., 57:3290, 1966.PubMedGoogle Scholar
  6. 6.
    C. Sirtori, Lancet, i:215, 1967.CrossRefGoogle Scholar
  7. 7.
    D. E. R. Sutherland, O. K. Archer, and R. A. Good, Proc. Soc. Exptl. Biol. Med., 115:673, 1964.Google Scholar
  8. 8.
    M. D. Cooper, D. Y. Perey, M. F. McKneally, A. E. Gabrielsen, D. E. R. Sutherland, and R. A. Good, Lancet, i:1388, 1966.CrossRefGoogle Scholar
  9. 9.
    R. A. Good and J. Finstad, in: H. Cottier, N. Odartchenko, R. Schindler, and C. C Congdon, Eds., Germinal Centers in Immune Responses, p. 4. New York: Springer-Verlag, 1967.CrossRefGoogle Scholar
  10. 10.
    H. D. Cooper, A. E. Gabrielsen, R. D. A. Peterson, and R. A. Good, in: H. Cottier, N. Odartchenko, R. Schindler, and C. C Congdon, Eds., Germinal Centers in Immune Responses, p. 28. New York: Springer-Verlag, 1967.CrossRefGoogle Scholar
  11. 11.
    P. A. Crabbe, Lab. Invest., 14:235, 1965.PubMedGoogle Scholar
  12. 12.
    C. Zanuzzi and F. Medina, in: V. Chini, L. Bonomo, and C. Sirtori, Eds., Proc. Intern. Symp. on Gammapathies, Infections, Cancer and Immunity, p. 68. Milano: Carlo Erba Foundation, 1968.Google Scholar
  13. 13.
    P. Tolentino, Le epatiti infettive virali con particolare riguardo all’infanzia. Ed. Minerva Medica, Torino, 1966.Google Scholar
  14. 14.
    M. E. Conrad, F. D. Schwartz, and A. A. Young, Am. J. Med., 37:789, 1964.PubMedCrossRefGoogle Scholar
  15. 15.
    G. Astaldi, U. Grandini, C. Poggi, and E. Strosselli, Am. J. Digest. Diseases, 9:237, 1964.CrossRefGoogle Scholar
  16. 16.
    W. H. Crosby and H. W. Kugler, Am. J. Digest. Diseases, 2:236, 1957CrossRefGoogle Scholar
  17. 17.
    J. Brächet, in: E. Chargaff and J. N. Davidson, Eds., Chemistry and Biology, Vol. II, p. 519. New York: Academic Press, 1955.Google Scholar
  18. 18.
    M. D. Cooper, D. R. R. Sutherland, and R. A. Good, Nature, 205:143, 1965.PubMedCrossRefGoogle Scholar
  19. 19.
    K. E. Fichtelius, Exptl. Cell Res., 46:231, 1967.PubMedCrossRefGoogle Scholar
  20. 20.
    R. A. Good, M. D. Cooper, R. D. A. Peterson, J. R. Hoyer, and A. E. Gabrielsen, in: H. Cottier, N. Odartchenko, R. Schindler, and C. C Congdon, Eds., Germinal Centers in Immune Responses, p. 387. New York: Springer-Verlag, 1967.Google Scholar
  21. 21.
    M. W. Elves, The Lymphocytes. London: Lloyd-Luke (medical books) Ltd., 1966.Google Scholar
  22. 22.
    K. Lennert, Verhandl. Deut. Ges. Pathol., 50:163, 1966.Google Scholar
  23. 23.
    R. Airo and G. Astaldi, Haematol. Latina, 10:209, 1967.Google Scholar
  24. 24.
    P. A. Crabbe and J. F. Heremans, Gut, 7:119, 1966.PubMedCrossRefGoogle Scholar
  25. 25.
    J. H. Rippey and S. C. Sommers, Am. J. Digest. Diseases, 12:465,1967.CrossRefGoogle Scholar
  26. 26.
    L. Ratto, G. Astaldi, M. C. Conrad, and G. Costa, Biochim. Biol. Sper., 3:165, 1965.Google Scholar
  27. 27.
    G. Astaldi, M. C. Conrad, and R. Airo, Am. J. Digest. Diseases, 11:53, 1966.CrossRefGoogle Scholar
  28. 28.
    R. Airo, M. C. Conrad, G. Astaldi, and T. Lisino, Frankfurter Z. Pathol., 75:269, 1966.Google Scholar
  29. 29.
    V. Pipitone, in: V. Chini, L. Bonomo, and C. Sirtori, Eds., Proc. Intern. Symp. on Gammapathies, Infections, Cancer and Immunity, p. 45. Milano: Carlo Erba Foundation, 1968.Google Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • G. Astaldi
    • 1
    • 2
    • 3
  • R. Airo
    • 1
    • 2
    • 3
  • M. E. Conrad
    • 1
    • 2
    • 3
  • R. Penna
    • 1
    • 2
    • 3
  • F. Ceretto
    • 1
    • 2
    • 3
  1. 1.The Blood Research Foundation CenterHospital of TortonaTortonaItaly
  2. 2.Institute of PathologyUniversity of MilanMilanItaly
  3. 3.Walter Reed Army Medical CenterUSA

Personalised recommendations