Clonal Compartmentation in the Antibody-Producing Lymph Node

  • A. O. Carbonara
  • A. L. Luzzati
  • R. M. Tosi
  • G. Mancini
  • R. Ceppellini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


The antibody synthesizing cell is specifically differentiated toward the production of an immunoglobulin belonging to a single class, exhibiting only one allelic allotypic specificity for each locus and probably possessing a single antibody activity [1, 2, 3, 4]. The antigenic stimulus is known to induce a complex set of events, including proliferation of immunocompetent cells [5, 6, 7, 8], in lymphopoietic tissue. If the specific differentiation is preserved through cell generations, the immunopoietic tissue should be constituted by more or less delimited clusters of cells sharing a common pattern of differentiation.


Goat Anti Rabbit Single Fragment Popliteal Lymph Node Somatic Antigen Agglutinate Activity 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • A. O. Carbonara
    • 1
  • A. L. Luzzati
    • 1
  • R. M. Tosi
    • 1
  • G. Mancini
    • 1
  • R. Ceppellini
    • 1
  1. 1.Istituto di Genetica MedicaUniversità di TorinoTorinoItaly

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