Clonal Compartmentation in the Antibody-Producing Lymph Node
The antibody synthesizing cell is specifically differentiated toward the production of an immunoglobulin belonging to a single class, exhibiting only one allelic allotypic specificity for each locus and probably possessing a single antibody activity [1, 2, 3, 4]. The antigenic stimulus is known to induce a complex set of events, including proliferation of immunocompetent cells [5, 6, 7, 8], in lymphopoietic tissue. If the specific differentiation is preserved through cell generations, the immunopoietic tissue should be constituted by more or less delimited clusters of cells sharing a common pattern of differentiation.
KeywordsGoat Anti Rabbit Single Fragment Popliteal Lymph Node Somatic Antigen Agglutinate Activity
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