Absence of Complement Binding by Immunoglobulin Aggregates in Germinal Centers
In various species, lacy networks of immunoglobulins have been demonstrated in most germinal centers by immunofluorescence . In the majority of cases these immunoglobulins are mixtures of molecules of different class, type, and allotype (see Pernis ) and are located in intercellular spaces, particularly close to membranes of the dendritic macrophages present in the centers. These intercellular deposits of immunoglobulins dominate the pattern demonstrable with fluorochrome-conjugated antisera and constitute an obstacle to the study of intracellular immunoglobulins actively synthesized by individual cells of the germinal centers.
KeywordsHuman Serum Albumin Lupus Nephritis Germinal Center Human Immunoglobulin Bence Jones Protein
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