Effect of Isogenic Red Blood Cells Transfusion on the Immune Response of Mouse Radiation Chimeras
Bone marrow cells transplanted into irradiated mice are able to repopulate the myeloid and lymphoid tissues of the recipients and give rise to mature cells of the hemopoietic and immune systems . If cells of both systems can derive from a common precursor cell, e.g., a multipotent stem cell of marrow origin, it may be possible to affect one differentiation pathway by blocking or stimulating another one. This possibility was investigated by studying the anti- sheep RBC hemolysin response in bone marrow radiation chimeras in which erythropoiesis has been depressed or stimulated. Preliminary results have been presented elsewhere .
KeywordsBone Marrow Cell Irradiate Mouse Erythroid Differentiation Multipotent Stem Cell Anemic Group
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