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Effect of Isogenic Red Blood Cells Transfusion on the Immune Response of Mouse Radiation Chimeras

  • G. Doria
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)

Abstract

Bone marrow cells transplanted into irradiated mice are able to repopulate the myeloid and lymphoid tissues of the recipients and give rise to mature cells of the hemopoietic and immune systems [1]. If cells of both systems can derive from a common precursor cell, e.g., a multipotent stem cell of marrow origin, it may be possible to affect one differentiation pathway by blocking or stimulating another one. This possibility was investigated by studying the anti- sheep RBC hemolysin response in bone marrow radiation chimeras in which erythropoiesis has been depressed or stimulated. Preliminary results have been presented elsewhere [2].

Keywords

Bone Marrow Cell Irradiate Mouse Erythroid Differentiation Multipotent Stem Cell Anemic Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    P. C. Koller, A. J. S. Davies, and S. Doak, Advan. Cancer Res., 8:181, 1961.Google Scholar
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    G. Doria, Federation Proc., 27:563, 1968.Google Scholar
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    G. Doria and G. Agarossi, Transplantation, 6:218, 1968.PubMedCrossRefGoogle Scholar
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    G. S. Hodgson, Blood, 19:460, 1962.PubMedGoogle Scholar
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    N. K. Jerne, A. A. Nordin, and C. Henry, in: B. Amos and H. Koprowski, Eds., Cell-Bound Antibodies, p. 109. Philadelphia: Wistar Institute Press, 1963.Google Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • G. Doria
    • 1
  1. 1.Laboratory of Animal Radiobiology, C.S.NCNEN-Euratom Immunogenetics GroupCasaccia (Rome)Italy

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