Chemical Inhibition of Blastic Transformation in Phytohemagglutinin-Stimulated Lymph Nodes
Local or systemic administration of phytohemagglutinin (PHA) to mice and rabbits has recently been shown to cause a sequence of striking histological changes in the peripheral lymphoid tissues [1, 2, 3]. It is fully recognized that PHA-induced blast cell formation in vivo may merely reflect the marked antigenicity of this substance and may have no bearing on the transformation phenomena observed in lymphocyte cultures. Still, the considerable rapidity and intensity of the reaction may render it a useful model system for the study of lymphocyte activation in the living animal.
KeywordsGerminal Center Chemical Inhibition Popliteal Lymph Node BLASTIC Transformation Cortisone Acetate
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