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Morphological Changes in Lymphoid Tissues of Mice Treated with Antilymphocyte Sera

  • L. Fiore-Donati
  • G. M. Cappuzzo
  • D. Collavo
  • N. Penelli
  • L. Chieco-Eianchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)

Abstract

The immunosuppressive effect of heterologous antilymphocyte serum (ALS) is now well established, although its mode of action is yet to be elucidated. Animals treated with ALS show an early remarkable decrease of blood lymphocytes associated with a profound immunological deficit, mainly with regard to cell-mediated immunity, as demonstrated by the suppression or impairment of skin and renal allograft rejection [1–3], lymphocytic choriomeningitis [4], Freud’s adjuvant arthritis [5], and other responses of the delayed type [6, 7]. In addition, lymphocytes from ALS-treated animals fail to initiate a graft-versus-host reaction in appropriate recipients [8–10]. On the other hand, antibody production, except for antibodies against red blood cells, does not seem to be affected to any comparable extent by ALS administration.

Keywords

Germinal Center Small Lymphocyte Outer Cortex Lymphocytic Choriomeningitis Lymphocyte Depletion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • L. Fiore-Donati
    • 1
  • G. M. Cappuzzo
    • 1
  • D. Collavo
    • 1
  • N. Penelli
    • 1
  • L. Chieco-Eianchi
    • 1
  1. 1.Istituto di Anatomia PatologicaUniversità di PadovaPadovaItaly

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