Further Studies on the Relation Between Germinal Centers and Cell-Mediated Injury

  • J. L. Turk
  • J. Oort
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


In the first conference on germinal centers in immune response, we presented evidence suggesting that germinal centers and plasma cell proliferation in the medulla were associated with the humoral antibody response, whereas proliferation of lymphocytes in the para-cortical areas of the lymph node, the area containing the mobile pool of small lymphocytes, was associated with specific cell-mediated immunity or delayed hypersensitivity [1]. It was also suggested that these two systems in the lymph node were distinct, both functionally and anatomically. Further studies over the past two years have confirmed this work and continued to emphasize the biologically distinct nature of these two systems in lymphoid tissue. These include the effect of antilymphocyte serum, which has a preferential effect in suppressing cell-mediated immunity rather than humoral antibody production, and deep X-irradiation in a dose that suppresses antibody production without affecting the ability of the animal to show delayed hypersensitivity. Finally, functional differences between these areas of tissue have been found in guinea pig, rat, mouse, and man by a histochemical study of the distribution of activity of the enzymes 5-nucleotidase, alkaline phosphatase, and ATPase in stimulated lymph nodes.


Germinal Center Small Lymphocyte Lepromatous Leprosy Lymph Follicle Human Lymph Node 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. L. Turk and J. Oort, in: H. Cottier, N. Odartchenko, R. Schindler, and C. C Congdon, Eds., Germinal Centers in Immune Responses, p. 311. New York: Springer-Verlag, 1967.CrossRefGoogle Scholar
  2. 2.
    J. L. Turk, D. A. Willoughby, and J. E. Stevens, Immunology, 14:683, 1968.PubMedGoogle Scholar
  3. 3.
    S. B. Salvin and R. F. Smith, J. Exptl. Med., 109:325, 1959.CrossRefGoogle Scholar
  4. 4.
    P. Schipior and H. C. Maguire, Intern. Arch. Allergy Appl. Immunol., 29:447, 1966.CrossRefGoogle Scholar
  5. 5.
    J. V. Diengdoh and J. L. Turk, Intern. Arch. Allergy Appl. Immunol., 29:224, 1966.CrossRefGoogle Scholar
  6. 6.
    P. Perlmann and O. Broberger, J. Exptl. Hed., 117:717, 1963.CrossRefGoogle Scholar
  7. 7.
    A. C. Alsenberg, J. Clin. Invest., 41:1964, 1962.Google Scholar
  8. 8.
    A. C. Aisenberg, J. Clin. Invest., 44:555, 1965.PubMedCrossRefGoogle Scholar
  9. 9.
    G. Krüger, J. Natl. Cancer Inst., 39:1, 1967.PubMedGoogle Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • J. L. Turk
    • 1
    • 2
  • J. Oort
    • 1
    • 2
  1. 1.Institute of DermatologyUniversity of LondonEngland
  2. 2.Pathological LaboratoryUniversity of LeidenThe Netherlands

Personalised recommendations