The Source of Cells within Different Areas of Lymph Nodes Draining the Site of Primary Stimulation with a Contact Sensitizing Agent
The cortex of the mouse lymph node can be clearly divided into two areas, a peripheral area of primary nodules, which are round, packed aggregations of lymphocytes, and midcortical area containing lymphocytes spread as a loose, wide sheet rather than as nodular aggregations like the periphery. The latter area of the lymph node, the paracortical area of Oort and Turk , has been called thymus- dependent for the following reasons: The depletion of lymphocytes seen in the lymph nodes of mice thymectomized at birth is primarily restricted to the paracortical area, leaving the primary nodules and medullary area relatively unaffected . Autoradiographic studies have demonstrated that thymus cells, whether labeled in vitro with 3H-adenosine and injected intravenously  or emigrating from a thymus graft labeled in vivo with 3H-thymidine  or from a thymus labeled in situ with 3H-thymidine , localize almost exclusively in the thymus-dependent areas of lymph nodes, often close to the postcapillary venules.
KeywordsLymphoid Tissue Spleen Cell Mouse Lymph Node Blast Cell Small Lymphocyte
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