The Source of Cells within Different Areas of Lymph Nodes Draining the Site of Primary Stimulation with a Contact Sensitizing Agent

  • Delphine M. V. Parrott
  • Maria A. B. de Sousa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


The cortex of the mouse lymph node can be clearly divided into two areas, a peripheral area of primary nodules, which are round, packed aggregations of lymphocytes, and midcortical area containing lymphocytes spread as a loose, wide sheet rather than as nodular aggregations like the periphery. The latter area of the lymph node, the paracortical area of Oort and Turk [1], has been called thymus- dependent for the following reasons: The depletion of lymphocytes seen in the lymph nodes of mice thymectomized at birth is primarily restricted to the paracortical area, leaving the primary nodules and medullary area relatively unaffected [2]. Autoradiographic studies have demonstrated that thymus cells, whether labeled in vitro with 3H-adenosine and injected intravenously [2] or emigrating from a thymus graft labeled in vivo with 3H-thymidine [3] or from a thymus labeled in situ with 3H-thymidine [4], localize almost exclusively in the thymus-dependent areas of lymph nodes, often close to the postcapillary venules.


Lymphoid Tissue Spleen Cell Mouse Lymph Node Blast Cell Small Lymphocyte 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • Delphine M. V. Parrott
    • 1
  • Maria A. B. de Sousa
    • 1
  1. 1.Department of Bacteriology and ImmunologyWestern InfirmaryGlasgowScotland

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