Regional Disparity of Germinal Center Development in Neonatally Thymectomized Mice After Stimulation with Tetanus Toxoid
Although the leading role of the thymus in establishing and maintaining the immunological competence of the mammalian organism is undisputed, many aspects of thymic function remain obscure. The importance of the thymus for humoral antibody formation appears to be particularly difficult to assess. The effects of thymectomy on antibody responsiveness of laboratory animals vary greatly, not only among the species studied and according to the age of the animals at the time of operation, but also with the general health of the animal colony and with type and physical form of the antigen used . In addition, the question of why anamnestic antibody responses to some antigens may be more impaired than primary responses in a number of neonatally thymectomized mice still remains unanswered [2–4].
KeywordsGerminal Center Mouse Lymph Node Mesenteric Lymph Node Tetanus Toxoid Popliteal Lymph Node
Unable to display preview. Download preview PDF.
- 1.M. W. Hess, in: R. Hegglin, F. Leuthardt, R. Schoen, H. Schwiegk, A. Studer, and H. U. Zollinger, Eds., Experimentelle Medizin, Pathologie und Klinik, Bd. 25. Berlin-Heidelberg-New York: Springer-Verlag, 1968.Google Scholar
- 8.N. W. Smirnow and I. W. Dunin-Barkowski, Mathematische Statistik in der Technik, pp. 236–239. Berlin: VEB Deutscher Verlag der Wissenschaften, 1963.Google Scholar
- 11.R. Wilson, K. Sjodin, and M. Bealmear, in: V. Defendi and D. Hetcalf, Eds., The Thymus, p. 89. Philadelphia: The Wistar Institute Press, 1964.Google Scholar
- 12.H. A. Azar, J. Williams, and K. Takatsuki, in: V. Defendi and D. Metealf, Eds., The Thymus, p. 75. Philadelphia: The Wistar Institute Press, 1964.Google Scholar