Immune Response in Mice: A Comparison of the Secondary Immune Response and the Response Elicited with Immune Complexes

  • Geronimo Terres
  • Albert H. Coons
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


An enhancing influence of preexisting antibody on the magnitude of antibody response to an antigenic stimulus was first noted by Terres and Wolins [1]. Despite the general finding by many workers that passively administered antibody inhibits antibody formation (reviewed by Uhr and Möller [2]), the original observation has been repeatedly confirmed by the senior author and his colleagues (e.g., [3, 4]). The difference evidently is in the dosage and in the need for antigen excess or for the presence of antigen on two occasions, as suggested by Leduc et al. [5]. The kinetics and the quantity of antibody synthesized in such an enhanced response were indistinguishable from those of a secondary response (S. L. Morrison and G. Terres, unpublished); mouse anti-BSA appeared within 5 days of the booster or the antigen-antibody injection, and the peak titer was reached on about day 7.


Bovine Serum Albumin Immune Complex Ammonium Sulfate Tetanus Toxoid Fluorescent Cell 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • Geronimo Terres
    • 1
  • Albert H. Coons
    • 1
  1. 1.Department of Bacteriology and ImmunologyHarvard Medical SchoolBostonUSA

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