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Histologic Localization of Hemolysin-Containing Cells

  • Chapter
Lymphatic Tissue and Germinal Centers in Immune Response

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 5))

Abstract

The complexity of the cellular events that take place during antibody formation is emphasized by several recent studies. Induction of the antibody response requires interaction between several different types of cells that are derived from or have developed under the influence of different tissues [1, 2, 3, 4]. Once antibody production begins, several different molecular types of immunoglobulins may be formed. Phylogenetic, ontogenetic, and experimental data suggest that cells forming IgM and IgG antibody represent two distinct stages in the same cell lineage, if not two distinct cell lines [5, 6, 7]. Antibody-releasing cells arising during the immune response can be enumerated by the technique of localized hemolysis in gel [8, 9]. This method, however, provides no information concerning the histologic relationships of such cells within lymphoid tissues. The present studies were undertaken to determine the histologic location of antibody-containing cells in an attempt to determine sites of cellular interactions.

U. S. Public Health Service Postdoctorate Trainee Grant AI-96.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Chicago, The Argonne Cancer Research Hospital, Chicago, Illinois, USA

    F. W. Fitch, R. Stejskal & D. A. Rowley

Authors
  1. F. W. Fitch
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  2. R. Stejskal
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  3. D. A. Rowley
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Editor information

Editors and Affiliations

  1. Institute of Pathological Anatomy, University of Padua, Padua, Italy

    L. Fiore-Donati

  2. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    M. G. Hanna Jr.

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© 1969 Plenum Press

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Fitch, F.W., Stejskal, R., Rowley, D.A. (1969). Histologic Localization of Hemolysin-Containing Cells. In: Fiore-Donati, L., Hanna, M.G. (eds) Lymphatic Tissue and Germinal Centers in Immune Response. Advances in Experimental Medicine and Biology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3192-6_24

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  • DOI: https://doi.org/10.1007/978-1-4684-3192-6_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3194-0

  • Online ISBN: 978-1-4684-3192-6

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