Localization by Immunofluorescence of 19S and 7S Immunoglobulin in the Lymphoid Tissue of the Chicken and its Relation to Specific Antibody Production

  • V. I. French
  • P. C. Wilkinson
  • R. G. White
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


During the course of an immune response, studied by immuno-histochemical techniques, specific antibody has been shown to make its appearance in germinal centers of lymnh nodes of the rabbit [1] and in germinal centers of the spleen in the chicken [2]. Using the same technique, Ortega and Mellors [3] demonstrated the presence of immunoglobulins in the germinal centers of human lymph nodes and spleen, the variability of the pattern of immunoglobulin localization has made interpretation of these findings difficult. A comparison has therefore been made, by using the fluorescent antibody technique, between the cellular localization of chicken 19S and 7S immunoglobulins and the cellular immune response following injection of a soluble protein antigen, human serum albumin (HSA).


Dendritic Cell Human Serum Albumin Germinal Center Single Intravenous Injection Fluorescence Micrograph 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • V. I. French
    • 1
  • P. C. Wilkinson
    • 1
  • R. G. White
    • 1
  1. 1.Department of Bacteriology and ImmunologyUniversity of GlasgowScotland

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