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Detection of Virus Particles in Lymphatic Tissue Germinal Centers

  • D. C. Swartzendruber
  • Booe Il Ma
  • W. H. Murphy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)

Abstract

We previously reported the detection by electron microscopy of many C-type murine leukemia virus particles in lymphatic tissue (spleen, mesenteric lymph node) germinal -centers of C58 mice [1]. Virus particles were observed in germinal centers of this high leukemic mouse strain (>90% by 14 months old) between 3 and 9 months, or throughout the relatively long period of leukemia development, C-type virus particles were not restricted to germinal centers of the spleen and lymph nodes; however, their abundance in these sites was pronounced. Subsequently, the detection of viruslike particles in germinal centers of another species, nonleukemic Hartley strain guinea pigs, has been reported [2].

Keywords

Virus Particle Germinal Center Mesenteric Lymph Node Leukemia Development Reticular Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • D. C. Swartzendruber
    • 1
  • Booe Il Ma
    • 1
  • W. H. Murphy
    • 1
  1. 1.Department of MicrobiologyUniversity of MichiganAnn ArborUSA

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