Detection of Virus Particles in Lymphatic Tissue Germinal Centers

  • D. C. Swartzendruber
  • Booe Il Ma
  • W. H. Murphy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


We previously reported the detection by electron microscopy of many C-type murine leukemia virus particles in lymphatic tissue (spleen, mesenteric lymph node) germinal -centers of C58 mice [1]. Virus particles were observed in germinal centers of this high leukemic mouse strain (>90% by 14 months old) between 3 and 9 months, or throughout the relatively long period of leukemia development, C-type virus particles were not restricted to germinal centers of the spleen and lymph nodes; however, their abundance in these sites was pronounced. Subsequently, the detection of viruslike particles in germinal centers of another species, nonleukemic Hartley strain guinea pigs, has been reported [2].


Virus Particle Germinal Center Mesenteric Lymph Node Leukemia Development Reticular Network 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • D. C. Swartzendruber
    • 1
  • Booe Il Ma
    • 1
  • W. H. Murphy
    • 1
  1. 1.Department of MicrobiologyUniversity of MichiganAnn ArborUSA

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