Kinetic Studies on the Induction of Immune Tolerance to Protein Antigen in Sublethally X-Irradiated Rabbits

  • David Nachtigal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


Immune tolerance is a phenomenon resulting from the interaction of antigen with cells of the immune mechanism under conditions that are far from being understood. The original assumption as formulated by Medawar [1] and Dresser [2] suggests that tolerance is the outcome of antigen interplay with immature target cells. With the accumulation of quantitative data it was later suggested that tolerance may result from the “overloading” of a small number of competent cells with a relatively large amount of antigen.


Human Serum Albumin Immune Tolerance Protein Antigen Tolerance Induction Immune Recovery 


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  1. 1.
    P. B. Medawar, in: C. E. W. Wolstenholme and M. O’Connor, Eds., Ciba Foundation Symposium on Cellular Aspects of Immunity, p. 134, London: Churchill, 1960.Google Scholar
  2. 2.
    D. W. Dresser, Immunology, 5:161, 1962.PubMedGoogle Scholar
  3. 3.
    N. A. Mitchison, Proc. Roy. Soc. (London) Ser. B, 161:275, 1965CrossRefGoogle Scholar
  4. 4.
    D. Nachtigal and M. Feldman, Immunology, 6:356, 1963.PubMedGoogle Scholar

Copyright information

© Plenum Press 1969

Authors and Affiliations

  • David Nachtigal
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovothIsrael

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