The Immunologic Specificity of Ferritin Uptake by Macrophages in the Rat
It has been shown repeatedly that the process of phagocytosis by macrophages is a relatively nonspecific phenomenon involving the uptake of many nonantigenic and autologous substances as well as antigens. As a consequence, it would be natural to question the existence of an antigen-specific recognition system at this level. In fact, our finding that heterologous ferritin was pinocytized by small lymphocytes within minutes after injection into the footpad of the normal rat led us to suspect that perhaps an early antigen-recognition system might better be ascribed to the small lymphocyte rather than the macrophage . In order to gain more information on the very early events involving phagocytosis of antigen by cells, we have designed experiments in which the relative uptake by macrophages and lymphocytes of heterologous, homologous, and isologous ferritin is being evaluated by both radioautographic and electron microscopic observation. Although the experimentation has been completed, our observations are still preliminary. Accordingly, we would like to record at this time only the results of initial study of the macrophage.
KeywordsGerminal Center Popliteal Lymph Node Littoral Cell Heterologous Antigen Hemagglutination Titer
Unable to display preview. Download preview PDF.