Lymphatic Drainage of Thymic Lymphocytes in Mice
A better knowledge of lymphocyte emigration from the thymus to other sites of the organism is relevant to the understanding of thymic functions. It has long been postulated that such a cell traffic does exist, and Kindred  estimated that from 80 to 90% of thymic lymphoid cells leave the organ. Direct evidence for lymphocyte emigration from the thymus to distant lymphoreticular organs was obtained by labeling techniques [2, 3]. The first experiments using 3H-thymidine as a cell marker seemed to indicate that the magnitude of lymphocyte emigration from the thymus was small , and the overwhelming majority of lymphocytes produced in the thymic cortex disintegrate within the organ . It now appears, however, that thymic lymphocytes emigrate in great numbers, both in newborn [5, 6] and in young adult laboratory animals [7, 8, 9, 10, 11].
KeywordsLabel Index Lymphoid Cell Germinal Center Thymic Lymphocyte Corticomedullary Junction
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