Lymphatic Drainage of Thymic Lymphocytes in Mice

  • Ch E. Slonecker
  • B. Sordat
  • M. W. Hess
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)


A better knowledge of lymphocyte emigration from the thymus to other sites of the organism is relevant to the understanding of thymic functions. It has long been postulated that such a cell traffic does exist, and Kindred [1] estimated that from 80 to 90% of thymic lymphoid cells leave the organ. Direct evidence for lymphocyte emigration from the thymus to distant lymphoreticular organs was obtained by labeling techniques [2, 3]. The first experiments using 3H-thymidine as a cell marker seemed to indicate that the magnitude of lymphocyte emigration from the thymus was small [3], and the overwhelming majority of lymphocytes produced in the thymic cortex disintegrate within the organ [4]. It now appears, however, that thymic lymphocytes emigrate in great numbers, both in newborn [5, 6] and in young adult laboratory animals [7, 8, 9, 10, 11].


Label Index Lymphoid Cell Germinal Center Thymic Lymphocyte Corticomedullary Junction 
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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • Ch E. Slonecker
    • 1
  • B. Sordat
    • 1
  • M. W. Hess
    • 2
  1. 1.Institute of PathologyUniversity of BernBernSwitzerland
  2. 2.Theodor Kocher InstituteUniversity of BernBernSwitzerland

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