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Lymphatic Drainage of Thymic Lymphocytes in Mice

  • Ch E. Slonecker
  • B. Sordat
  • M. W. Hess
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 5)

Abstract

A better knowledge of lymphocyte emigration from the thymus to other sites of the organism is relevant to the understanding of thymic functions. It has long been postulated that such a cell traffic does exist, and Kindred [1] estimated that from 80 to 90% of thymic lymphoid cells leave the organ. Direct evidence for lymphocyte emigration from the thymus to distant lymphoreticular organs was obtained by labeling techniques [2, 3]. The first experiments using 3H-thymidine as a cell marker seemed to indicate that the magnitude of lymphocyte emigration from the thymus was small [3], and the overwhelming majority of lymphocytes produced in the thymic cortex disintegrate within the organ [4]. It now appears, however, that thymic lymphocytes emigrate in great numbers, both in newborn [5, 6] and in young adult laboratory animals [7, 8, 9, 10, 11].

Keywords

Label Index Lymphoid Cell Germinal Center Thymic Lymphocyte Corticomedullary Junction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1969

Authors and Affiliations

  • Ch E. Slonecker
    • 1
  • B. Sordat
    • 1
  • M. W. Hess
    • 2
  1. 1.Institute of PathologyUniversity of BernBernSwitzerland
  2. 2.Theodor Kocher InstituteUniversity of BernBernSwitzerland

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