Approaches to Brain Amines in Psychiatric Patients: A Reevaluation of Cerebrospinal Fluid Studies

  • Robert M. Post
  • Frederick K. Goodwin


This chapter will focus on manipulation of monoamines in psychiatric patients specifically as they are reflected and documented by alterations in cerebrospinal fluid amine metabolites. Hypotheses relating alterations in central neurotransmitter amine systems to the pathophysiology of manic-depressive illness and schizophrenia have provided a driving force toward the study of alterations in amine metabolism in psychiatric patients; these theories are reviewed elsewhere in this volume and will not be represented here in detail. However, on the basis of our review of the literature of cerebrospinal fluid (CSF) amine metabolites in psychiatric patients on and off medication, a critical evaluation and reformulation of amine theories will be offered. Special focus will be given to the time course of biological changes at the synapse, especially more chronic, long-term compensatory and adaptive mechanisms which may be critical to an understanding of the nature of biochemical-behavioral linkage.


Psychiatric Patient Homovanillic Acid Fusaric Acid Dopamine Turnover Affective Illness 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Robert M. Post
    • 1
  • Frederick K. Goodwin
    • 2
  1. 1.Section on Psychobiology, Biological Psychiatry BranchNational Institute of Mental HealthBethesdaUSA
  2. 2.Clinical Psycho-biology BranchNational Institute of Mental HealthBethesdaUSA

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