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The Limbic-Hypothalamic-Pituitary-Adrenal System and Human Behavior

  • William T. CarpenterJr.
  • Peter H. Gruen

Abstract

Following the pioneering work of Hans Selye (1950) the pituitary-adrenal system has been regarded as critical to the individual’s adaptation to changing internal and external environment. This endocrine system has been found responsive to input ranging from shifts in intracellular electrolyte composition to fantasized danger, and its hormonal secretions implicated in the regulation of events ranging from gluconeogenesis to mood. What makes this system relevant to a volume on psychopharmacology is the intricate relationship between distressing subjective experience and neuroendocrine function, a relationship which is subject to pharmacologic modification on both sides of the interface.

Keywords

Plasma Cortisol Corticotropin Release Factor Cortisol Secretion Depressive Illness ACTH Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Addison, T., 1868, On the constitutional and local effect of the suprarenal capsules, in: A Collection of the Published Writings of Thomas Addison, Vol. XXXVI, New Sydenham Society, London.Google Scholar
  2. Allen, J. P., Denney, D., Kendall, J. W., and Blachly, P. H., 1974, Corticotropine release during ECT in man, Am. J. Psychiatry131:1225–1228.PubMedGoogle Scholar
  3. Asano, Y., and Moroji, T., 1974, Effects of metamphetamine on daily rhythms of hypothalamic norepinephrine, serotonin and plasma corticosterone levels in the rat, Life Sci.14:1463–1472.PubMedGoogle Scholar
  4. Axelrod, J., and Weinshilboum, R., 1972, Catecholamines, Physiol. Med.287:237–242.Google Scholar
  5. Azmitia, E. C., and McEwen, B. S., 1969, Corticosterone regulation of tryptophan hydroxylase in midbrain of the rat, Science166:1274–1276.PubMedGoogle Scholar
  6. Bohus, B., 1969, Central nervous system structures and the effect of ACTH and corticosteroids on avoidance behavior, in: Progress in Brain Research (D. De Wied and J. A. W. N. Weigneh, eds.), pp. 171–184, Elsevier, Amsterdam.Google Scholar
  7. Borman, M. C., and Schmallenberg, H. C., 1951, Suicide following cortisone treatment, J. Am. Med. Assoc.146:337–338.PubMedGoogle Scholar
  8. Brodle, B. B., Davies, J. I., Hynie, S., Krishna, G., and Weiss, B., 1966, Interrelationships of catecholamines with other endocrine systems, Pharmacol. Rev.18:273–289.Google Scholar
  9. Brown, G. M., 1975, Psychiatric and neurologic aspects of endocrine disease, Hosp. Pract.10:71–79.Google Scholar
  10. Brownstein, M. J., Palkouits, M., Saavedra, J. M., and Kizer, J. S., 1976, Distribution of hypothalamic hormones and neurotransmitters within the diencephalon, in: Frontiers in Neuroendocrinology (L. Martini and W. F. Ganong, eds.), pp. 1–23, Raven Press, New York.Google Scholar
  11. Butler, P. W. P., and Besser, G. M., 1968, Pituitary-adrenal function in severe depressive illness, Lancet2:1234–1236.Google Scholar
  12. Butler, P. W. P., Besser, G. M., and Steinberg, H., 1968, Changes in plasma Cortisol induced by dexamphetamine and chlordiazepoxide given alone and in combination in man, J. Endocrinol.40:391–392.PubMedGoogle Scholar
  13. Bunney, W. E., Jr., 1969, Psychoendocrine parameters and psychopathology, in: Methods and Theory in Psychochemical Research in Man (A. J. Mandell and M. P. Mandell, eds.), pp. 193–217, Academic, New York.Google Scholar
  14. Bunney, W. E., and Davis, J. M., 1965, Norepinephrine in depressive reaction, Arch. Gen. Psychiatry13:483–494.PubMedGoogle Scholar
  15. Bunney, W. E., Jr., Mason, J., Roatch, J., and Hamburg, D. A., 1965, A psychoendocrine study of severe psychotic depressive crises, Am. J. Psychiatry122:72–80.Google Scholar
  16. Carpenter, W. T., 1970, Current status of serotonin in affective disorders, Ann. Intern. Med.73:607–629.Google Scholar
  17. Carpenter, W. T., and Bunney, W. E., 1971a, Adrenal cortical activity in depressive illness, Am.J. Psychiatry128:31–40.PubMedGoogle Scholar
  18. Carpenter, W. T., and Bunney, W. E., 1971b, Behavioral effects of Cortisol in man, Semin. Psychiatry3:421–434.PubMedGoogle Scholar
  19. Carpenter, W. T., and Bunney, W. E., 1971c, Diurnal rhythm of Cortisol in mania, Arch. Gen. Psychiatry25:270–273.Google Scholar
  20. Carroll, B. J., 1972, The hypothalamic-pituitary-adrenal axis, in: Depressive Illness (B. Davies, B. J. Carroll, and M. Mowbray, eds.), pp. 23–201, Charles C. Thomas, Springfield, Illinois.Google Scholar
  21. Carroll, B. J., 1976, Limbic system-adrenal cortex regulation in depression and schizophrenia, Psychosom. Med.38:106–121.PubMedGoogle Scholar
  22. Carroll, B. J., and Mendels, J., 1976, Neuroendocrine regulation in affective disorders, in: Hormones, Behavior and Psychopathology (E.J. Sachar, ed.), pp. 193–224, Raven Press, New York.Google Scholar
  23. Carroll, B. J., Martin, F. I. R., and Davies, B. M., 1968, Resistance to suppression by dexamethasone of plasma 11-OCHS levels in severe depressive illnesses, Br. Med. J.3:285–287.PubMedGoogle Scholar
  24. Carroll, B. J., Curtis, G. C., and Mendels, J., 1976a, Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction, Arch. Gen. Psychiatry33:1039–1044.PubMedGoogle Scholar
  25. Carroll, B. J., Curtis, G. C., and Mendels, J., 1976b, Neuroendocrine regulation in depression. II. Discrimination of depressed from nondepressed patients, Arch. Gen. Psychiatry33:1051–1058.PubMedGoogle Scholar
  26. Ceresa, F., Angel, A., Boccuzzi, G., and Molino, G., 1969, Once-a-day neurally stimulated and basal ACTH secretion phases in man and their response to corticoid inhibition, J. Clin. Endocrinol. Metab.29:1074–1082.PubMedGoogle Scholar
  27. Chambers, J. W., and Brown, G. M., 1976, Neurotransmitter regulation of growth hormone and ACTH in the rhesus monkey: Effects of biogenic amines, Endocrinology98:420–428.PubMedGoogle Scholar
  28. Clark, L. D., Bauer, W., and Cobb, S., 1952, Preliminary observations of mental disturbances occurring in patients under therapy with cortisone and ACTH, N. Engl. J. Med.264:205–216.Google Scholar
  29. Clark, L. D., Quartion, G. C., Cobb, S., and Bauer, W., 1953, Further observations on mental disturbances associated with cortisone and ACTH therapy, N. Engl. J. Med.249:178–183.PubMedGoogle Scholar
  30. Cleghorn, R. A., 1951, Adrenal cortical insufficiency. Psychological and neurological observations, J. Can. Med. Assoc.65:449–454.Google Scholar
  31. Coppen, A., 1965, Mineral metabolism in affective disorders, Br. J. Psychiatry111:1133–1142.PubMedGoogle Scholar
  32. Coppen, A., and Kessel, N., 1963, Menstruation and personality, Br. J. Psychiatry109:711–721.PubMedGoogle Scholar
  33. Cotui, R. W., Brinitzer, W., Orr, A., and Orr, E., 1960, Effect of chlorpromazine and of reserpine on adrenocortical function, Psychiatr. Q.34:47–61.PubMedGoogle Scholar
  34. Cumming, J., and Kort, K., 1956, Apparent reversal by cortisone of an electroconvulsive refractor state in psychotic patients in Addison’s disease, Can. Med. Assoc. J.74:291–292.PubMedGoogle Scholar
  35. Cushing, H., 1932, The basophil adenomas of the pituitary body and their clinical manifestations, Johns Hopkins Med. J.50:137–195.Google Scholar
  36. Daughaday, W. H., 1974, The adenohypophysis, in: Textbook of Endocrinology (Robert H. Williams, ed.), pp. 31–79, W. B. Saunders, Philadelphia.Google Scholar
  37. De Villis, J., and Inglish, D., 1968, Hormonal control of glycerolphosphate dehydrogenase in the rat brain, Neurochemistry15:1061–1070.Google Scholar
  38. De Wied, D., 1974, Pituitary-adrenal system hormones and behavior, in: The Neurosciences Third Study Program (F. A. Schmitt and F. G. Worden, eds.), pp. 653–666, MIT Press, Cambridge, Massachusetts.Google Scholar
  39. De Wied, D., and De Jong, W., 1974, Drug effects and hypothalamic-anterior pituitary function. Annu. Rev. Pharmacol.14:389–411.Google Scholar
  40. De Wied, D., Witter, A., and Lande, S., 1969, Anterior pituitary peptides and avoidance acquisition of hypophysectomized rats, in: Progress in Brain Research (D. De Wied and J. A. W. N. Weijnen, eds,). pp. 213–220, Elsevier, Amsterdam.Google Scholar
  41. Edstrom, J. E., and Eichner, D., 1958, Relation between nucleolar volume and cell body content of ribonucleic acid in supraoptic neurones, Nature181:619.PubMedGoogle Scholar
  42. Egdahl, R. H., 1968, Excitation and inhibition of ACTH secretion, Mem. Soc. Endocrinol.17:29–37.Google Scholar
  43. Endicott, N. A., and Gralnick, A., 1961, Psychosomatic aspects of hyperadrenocorticism treated with chlorpromazine, Dis. Nerv. Syst.22:680–687.Google Scholar
  44. Endo, M., Endo, J., Nislikubo, M., Yamaguchi, T., and Hatotani, N., 1974, Endocrine studies in depression, in: Psychoneuroendocrinology (N. Hatotani, ed.), pp. 22–31, Karger, Basel.Google Scholar
  45. Engel, G. L., and Margolin, S. G., 1941, Neuropsychiatric disturbances in Addison’s disease and role of impaired carbohydrate in production of abnormal cerebral function, Arch. Neurol. Psychiatry45:881–884.Google Scholar
  46. Engel, G. L., and Margolin, S. G., 1942, Neuropsychiatric disturbances in internal disease, Arch. Intern. Med.70:236–259.Google Scholar
  47. Fawcett, J. A., and Bunney, W. E., Jr., 1967, Pituitary adrenal function and depression: An outline for research, Arch. Gen. Psychiatry16:517–525.PubMedGoogle Scholar
  48. Feldman, S., and Dafny, N., 1969, Effects of adrenocortical hormones on electrical activity of the brain, in: Progress in Brain Research (D. De Wied and J. A. W. N. Weijnen, eds.), pp. 90–101, Elsevier, Amsterdam.Google Scholar
  49. Forsham, P. H., 1968, The adrenal cortex, in: Textbook of Endocrinology (R. H. Williams, ed.), pp. 287–379, W. B. Saunders, Philadelphia.Google Scholar
  50. Fox, H. M., and Gifford, S., 1953, Psychological responses to ACTH and cortisone, Psychosom. Med.15:631–641.Google Scholar
  51. Frohman, L. A., 1975, Neurotransmitters as regulators of endocrine function, Hosp. Pract.10:54–62.Google Scholar
  52. Frohman, L. A., and Stachura, M. E., 1975, Neuropharmacologic control of neuroendocrine function in man, Metabolism24:211–234.PubMedGoogle Scholar
  53. Galdston, M., Weisenfeld, S., Benjamin, B., and Rosenfeld, M., 1951, Effect of ACTH in chronic lung disease; study of five patients, Am. J. Med.10:166–181.PubMedGoogle Scholar
  54. Gallagher, T. F., Yoshida, K., Roffwarg, H., Fukushima, D., Weitzman, E. D., and Hellman, L., 1973, ACTH and Cortisol secretory patterns in man, J. Clin. Endocrinol. Metab.36:1058–1068.PubMedGoogle Scholar
  55. Ganong, W. F., 1970, Control of adrenocorticotropin and melanocyte-stimulating hormone secretion, in: The Hypothalamus (L. Martini, M. Motta, and F. Fraschini, eds.), pp. 313–333, Academic Press, New York.Google Scholar
  56. Ganong, W. F., 1972, Evidence for a central noradrenergic system that inhibits ACTH secretion, in: Brain Endocrine Interaction Median Eminence: Structure and Function (K. M. Knigge, D. E. Scott, A. Wendl, eds.), pp. 254–266, Karger, Basel.Google Scholar
  57. Ganong, W. F., 1974, The role of catecholamines and acetylcholine in the regulation of endocrine function, Life Sci.15:1401–1414.PubMedGoogle Scholar
  58. Ganong, W. F., Alpert, L. C., and Lee, T. C., 1974, ACTH and the regulation of adrenocortical secretion, N. Engl. J. Med.290:1006–1011.PubMedGoogle Scholar
  59. Genazzani, A. P., Lemarchand-Béraud, T. N., Aubert, M. L., and Felber, J. P., 1975, Pattern of plasma ACTH, HGH, and Cortisol during menstrual cycle, J. Endocrinol. Metab.41:431–437.Google Scholar
  60. Gibbons, J. L., and Fahy, T. J., 1973, Effect of dexamethasone on plasma corticosteroids in depressive illness, Neuroendocrinology1:358–363.Google Scholar
  61. Gibbs, F. P., 1969, Area of pons necessary for traumatic stress-induced ACTH release under pentobarbital anaesthesia, Am. J. Physiol.217:84–88.PubMedGoogle Scholar
  62. Gillham, B., Jones, M. T., Hillhouse, E. W., and Burden, J. L., 1977a, Preliminary observations on the nature of corticotrophin-releasing hormone from the rat hypothalamus in vitro, J. Endocrinol, (in press).Google Scholar
  63. Gillham, B., Burden, J. L., Hillhouse, E. W., and Jones, M. T., 1977b, The preparation of the rat hypothalamus in vitro as a source of CRH, J. Endocrinol, (in press).Google Scholar
  64. Glaser, G. H., 1953a, Psychotic reaction induced by corticotropin (ACTH) and cortisone, Psychosom. Med.15:280–291.PubMedGoogle Scholar
  65. Glaser, G. H., 1953b, The pituitary gland in relation to cerebral metabolism and metabolic disorders of the nervous system, Res. Publ. Assoc. Res. Nerv. Ment. Dis.32:21–39.PubMedGoogle Scholar
  66. Gold, E. M., and Ganong, W. F., 1967, Drug effects on neuroendocrine processes, in: Neuroendocrinology (L. Martini and W. F. Ganong, eds.), pp. 377–437, Academic Press, New York.Google Scholar
  67. Gold, E. M., Di Raimondo, V. C., Kent, J. R., Forsham, P. H., 1960, Comparative effects of certain nonnarcotic central nervous system analgesics and muscle relaxants on the pituitary-adrenocortical system, Ann. N.Y. Acad. Sci.86:178–190.PubMedGoogle Scholar
  68. Golstein, J., Van Couter, E., Leclercq, R., Copinschi, G., and Vanhaelst, L., 1974, Monthly variations of serum levels of thyrotropin growth hormone and Cortisol in man, Horm. Metab. Res.6:506–509.PubMedGoogle Scholar
  69. Gruen, P. H., Sachar, E. J., Altman, N., Langer, G., and Halpern, F. S., 1977, Psychotropic drugs and neuroendocrine function in psychopathological conditions, in: Collequiem Internationale Neuro-Psychopharmacoloquium (P. Deniker, C. Raduoco-Thomas, and A. Villaneuve, eds.), Pergamon Press, Oxford (in press).Google Scholar
  70. Guillemin, R., 1967, The adenohypophysis and its hypothalamic control, Annu. Rev. Physiol.29:313–348.PubMedGoogle Scholar
  71. Guillemin, R., Hearn, W. R., Cheek, W. R., Housholder, D. E., 1957, Control of corticotrophin release: Further studies with in vitro methods, Endocrinology60:488–506.PubMedGoogle Scholar
  72. Halasz, B., Slusher, M. A., and Gorski, R. A., 1967, Adrenocorticotrophic hormone secretion in rats after partial or total deafferentation of the medial basal hypothalamus, Neuroendocrinology2:43–55.Google Scholar
  73. Hartmann, F. A., Beck, G. M., and Thorn, G. W., 1933, Improvement in nervous and mental state under cortin therapy, J. Nerv. Ment. Dis.77:1–21.Google Scholar
  74. Haynes, R. C., and Larner, J., 1975, Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of adrenocortical steroid biosynthesis, in: The Pharmacological basis of Therapeutics, 5th ed. (Louis S. Goodman and Alfred Gilman, eds.), pp. 1472–1506, Macmillan, New York.Google Scholar
  75. Hedge, G. A., and De Wied, D., 1971, Corticotrophin and vasopressin secretion after hypothalamic implantation of atropine, Endocrinology88:257–259.Google Scholar
  76. Hedge, G. A., and Smelik, P. G., 1968, Corticotrophin release: Inhibition by intrahypothal-amic implantation of atropine, Science159:890–892.Google Scholar
  77. Hellman, L., Nakada, F., Curti, J., Weitzman, E. D., Kream, J., Roffwarg, H., Ellman, S., Fukushima, D. K., and Gallagher, T. F., 1970, Cortisol is secreted episodically by normal man, J. Clin. Endocrinol. Metab.30:411–422.PubMedGoogle Scholar
  78. Henderson, E., Lipmann, M., 1969, Personal communication.Google Scholar
  79. Hess, W. R., (ed.), 1954, Diencephalon, Autonomic and Extrapyramidal Functions, Grune, New York.Google Scholar
  80. Jakobson, T., Stenback, A., Strandstrom, L., and Rimon, R., 1966, The excretion of urinary 11-deoxy- and 11-oxy-17-hydroxy-corticosteroids in depressive patients during basal conditions and during the administration of methopyrapone, J. Psychosom. Res.9:363–374.PubMedGoogle Scholar
  81. Jones, M. T., Hillhouse, E., and Burden, J., 1976. Secretion of corticotropin-releasing hormone in vitro, in: Frontiers in Neuroendocrinology, Vol. 4 (L. Martini and W. F. Ganong, eds.), pp. 195–226, Raven Press, New York.Google Scholar
  82. Kothari, N. J., Saunders, J. C., and Kline, N. S., 1961, Effect of phenothiazines and hydrazines on pituitary-adrenal-cortical response, Psychopharmacologia (Berlin)2:22–26.Google Scholar
  83. Krieger, D. T., 1973. Neurotransmitter regulation of ACTH release. Mt. Sinai J. Med.40:302–314.PubMedGoogle Scholar
  84. Krieger, D. T., 1975, Rhythms of ACTH and corticosteroid secretion in health and disease, and their experimental modification, J. Steroid Biochem.6:785–791.PubMedGoogle Scholar
  85. Krieger, D., 1976, The Brain and the Endocrine System Symposium, Long Beach, California, June 18–19.Google Scholar
  86. Krieger, D. T., and Krieger, H. P., 1967a, The effect of short-term administration of CNS-acting drugs on the circadian variation of the plasma 17-OHCS in normal subjects, Neuroendocrinology2:232–246.Google Scholar
  87. Krieger, D. T., and Krieger, H. P., 1967b, Circadian pattern of plasma 17-hydroxycortico-steroid: Alteration by anticholinergic agents, Science155:1421–1422.PubMedGoogle Scholar
  88. Krieger, D. T., and Krieger, H. P., 1970, Chemical stimulation of the brain: Effect on adrenal corticoid release, A m. J. Physiol.218:1632–1641.Google Scholar
  89. Krieger, D. T., and Rizzo, F., 1969, Serotonin mediation of circadian periodicity of plasma 17-hydroxycorticosteroids, Am. J. Physiol.217:1703–1707.PubMedGoogle Scholar
  90. Krieger, D. T., Silverberg, A. I., Rizzo, F., and Krieger, H. P., 1968, Abolition of circadian periodicity of plasma 17-OHCS levels in the cat, Am. J. Physiol.215:959–967.PubMedGoogle Scholar
  91. Krieger, D., Allen, W., Rizzo, F., and Krieger, H., 1971, Characterization of the normal temporal pattern of plasma corticosteroid levels, J. Clin. Endocrinol. Metab.32:266–284.PubMedGoogle Scholar
  92. Kurland, H. D., 1965, Physiologic treatment of depressive reaction: A pilot study, Am. J. Psychiatry122:457–458.PubMedGoogle Scholar
  93. Kurland, H. D., and Freedberg, A. S., 1951, The potentiating effect of cortisone on pressor response to intravenous infusion of L-norepinephrine, Proc. Soc. Exp. Biol. Med.78:28–31.PubMedGoogle Scholar
  94. Labrie, F., Pelletier, G., Borgeat, P., Drovin, J., Ferland, L., and Belanger, A., 1976, Mode of action of hypothalamic regulatory hormones in the adenohypophysis, in: Frontiers in Neuroendocrinology, Vol. 4 (L. Martini, and W. F. Ganong, eds.), pp. 63–93, Raven Press, New York.Google Scholar
  95. Liddle, G. W., 1974, The adrenals, in: Textbook of Endocrinology (Robert H. Williams, ed.), pp. 233–283, W. B. Saunders, Philadelphia.Google Scholar
  96. Lidz, T., Carter, J. D., Lewis, B. I., and Surratt, C., 1952, Effects of ACTH and cortisone on mood and mentation, Psychosom. Med.14:363–377.PubMedGoogle Scholar
  97. Livingston, K. E., and Escobar, A., 1971, Anatomical basis of the limbic system concept, Arch. Neurol.24:17–21.PubMedGoogle Scholar
  98. Maas, J., 1972, Adrenocortical steroid hormones, electrolytes and the disposition of the catecholamines with particular reference to depressive states, J. Psychiatr. Res.9:227–241.PubMedGoogle Scholar
  99. MacLean, P. D., 1949, Psychosomatic disease and the ‘visceral brain.’ Recent developments bearing on the Papez theory of emotion, Psychosom. Med.11:338–353.PubMedGoogle Scholar
  100. MacLean, P. D., 1970, The limbic brain in relation to the psychoses, in: Physiological Correlates of Emotion (P. Black, ed.), pp. 129–146, Academic Press, New York.Google Scholar
  101. Mandell, A. J., Chapman, L. F., Rand, R. W., and Walter, R. D., 1963, Plasma corticosteroids: Changes in concentration after stimulation of hippocampus and amygdala, Science139:1212.PubMedGoogle Scholar
  102. Mangili, G., Motta, M., and Martini, L., 1966, Control of adrenocorticotrophic hormone secretion, in: Neuroendocrinology, Vol. 1 (L. Martini and W. F. Ganong, eds.), pp. 297–370, Academic Press, New York.Google Scholar
  103. Mason, J. W., 1968, A review of psychoendocrine research on the pituitary-adrenal cortical system, Psychosom. Med.30:576–607.PubMedGoogle Scholar
  104. McCann, S. M., and Porter, J. C., 1969, Hypothalamic pituitary stimulating and inhibiting hormones, Physiol. Rev.49:240–284.PubMedGoogle Scholar
  105. McClure, D. J., 1966, The effects of antidepressant medication on the diurnal plasma Cortisol levels in depressed patients, J. Psychosom. Res.10:197–202.Google Scholar
  106. McEwen, B. S., 1975, The brain as a target organ of endocrine hormones, Hosp. Pract.10:95–104.Google Scholar
  107. McEwen, B. S., Zigmond, R. E., and Gerlach, J. L., 1972, Sites of steroid binding and action in the brain, in: Structure and function of Nervous Tissue, Vol. 5 (Geoffrey H. Bourne, ed.), pp. 205–291, Academic Press, New York.Google Scholar
  108. Melmon, K. L., 1974, The endocrinologic manifestations of the carcinoid tumor, in: Textbook of Endocrinology (Robert H. Williams, ed.), pp. 1084–1104, W. B. Saunders, Philadelphia.Google Scholar
  109. Mendelson, J. H., Meyer, R. E., Ellingboe, J., Mirin, S. M., and McDougle, M., 1975, Effects of heroin and methadone on plasma Cortisol and testosterone. J. Pharmacol. Ther.195:296–302.Google Scholar
  110. Mess, B., 1969, Site and onset of production of releasing factors, in: Progress in Endocrinology, Proceedings of the Third International Congress of Endocrinology Mexico D.F., fune 30-fuly 5, 1968, pp. 564–570, Excerpta Medica Foundation, Amsterdam.Google Scholar
  111. Mess, B., and Martini, L., 1968, The central nervous system and the secretion of anterior pituitary-tropic hormones, in: Recent Advances in Endocrinology (V. H. T. James, ed.), pp. 1–49, Churchill, London.Google Scholar
  112. Moore, Robert Y., 1974, Visual pathways and the central neural control of diurnal rhythms, in: The Neurosciences Third Study Program (F. O. Schmitt and F. G. Worden, eds.), pp. 537–542, MIT Press, Cambridge, Massachusetts.Google Scholar
  113. Moscona, A. A., and Pidington, R., 1966, Stimulation by hydrocortisone of premature changes in the developmental pattern of glutamine synthetase in embryonic retina, Biochim. Biophys. Acta121:409–411.PubMedGoogle Scholar
  114. Muhlen, K., and Ockenfels, H., 1969, Morphological alterations in the diencephalon and telencephalon following disturbances of the feedback mechanism adenohypophysis adrenal cortex, Z. Zellforsch. Mikrosk. Anat.93:126–141.Google Scholar
  115. Mulder, A. H., 1970, On the subcellular localization of corticotropin releasing factor (CRF) in the rat median eminence, in: Pituitary, Adrenal and the Brain (D. De Wied and J. A. W. M. Weignen, eds.), pp. 33–41, Elsevier, Amsterdam.Google Scholar
  116. Murphy, D. L., Goodwin, F. K., and Bunney, W. E., 1972, Electrolyte changes in the affective disorders: Problems of specificity and significance, in: Recent Advances in Psychobiology of Depressive Illnesses (T. A. Williams, M. U. Katz, and J. A. Shield, eds.), pp. 59–70, U.S. Government Printing Office, Washington, D.C.Google Scholar
  117. Nakai, Y., Imura, H., Yoshimi, T., and Matsukura, S., 1973, Adrenergic control mechanism for ACTH secretion in man, Acta Endocrinol.74:263–270.PubMedGoogle Scholar
  118. Naumenko, E. V., 1968, Hypothalamic chemoreactive structure in the regulation of pituitary-adrenal-function: Effect of local injection of norepinephrine, carbachol, and serotonin into the brain of guinea pigs with intact brains and after mesencephalic transection, Brain Res.11:1–10.PubMedGoogle Scholar
  119. Nauta, W. J. H., 1963, Central nervous system organization and the endocrine motor system, in: Advances in Neuroendocrinology (A. V. Nalbandor, ed.), pp. 5–21, University of Illinois Press, Urbana.Google Scholar
  120. Nauta, W. J. H., 1975, Presented at Salmon Lecture, New York City, December 4.Google Scholar
  121. Orth, D. N., and Island, D. P., 1967, Experimental alteration of the circadian rhythm in plasma Cortisol (17-OHCS) concentration in man, J. Clin. Endocrinol.27:549–555.Google Scholar
  122. Papez, J. W., 1937, A proposed mechanism of emotion, Arch. Neurol. Psychiatry38:725–743.Google Scholar
  123. Pearson, O. H., and Eliel, L. P., 1950, Use of pituitary adrenocorticotropic hormone (ACTH) and cortisone in lymphomas and leukemias, J. Am. Med. Assoc.144:1349–1353.PubMedGoogle Scholar
  124. Pederson, K. O., 1967, Hypercalcemia in Addison’s disease, Acta Med. Scand.181:691–698.Google Scholar
  125. Pfaff, D. W., Silva, M. T., and Weiss, J. M., 1971, Telemetered recording of hormone effects on hippocampal neurons, Science172:394–395.PubMedGoogle Scholar
  126. Platman, S. R., and Fieve, R. R., 1968, Lithium carbonate and plasma Cortisol response in the affective disorders, Arch. Gen. Psychiatry18:591–594.PubMedGoogle Scholar
  127. Plonk, J. W., Bivens, C. H., and Feldman, J. M., 1974, Inhibition of hypoglycemia-induced Cortisol secretion by the serotonin antagonistic cyproheptadine, J. Clin. Endocrinol. Metab.38:836–840.PubMedGoogle Scholar
  128. Pohorecky, L. A., and Wurtman, R. J., 1971, Adrenocortical control of epinephrine synthesis, Pharmacol. Rev.23:1–35.PubMedGoogle Scholar
  129. Pohorecky, L. A., Zigmond, M., Karten, H., and Wurtman, R. J., 1969, Enzymatic conversion of norepinephrine to epinephrine of the brain, J. Pharmacol. Exp. Ther.165:190–195.PubMedGoogle Scholar
  130. Raisman, G., 1966, Neural connexions of the hypothalamus, Br. Med. Bull.22:197–201.PubMedGoogle Scholar
  131. Ramey, E. R., and Goldstein, M. S., 1957, The adrenal cortex and the sympathetic nervous system, Physiol. Rev.37:155–195.PubMedGoogle Scholar
  132. Rastogi, G. K., Dash, R. J., Sharma, B., Sawhney, R., and Sialy, R., 1976, Circadian responsiveness of the hypothalamic-pituitary axis, J. Clin. Endocrinol. Metab.42:798–803.PubMedGoogle Scholar
  133. Rees, L., 1953, Psychological concomitants of cortisone and ACTH therapy, J. Ment. Sci.99:497–504.PubMedGoogle Scholar
  134. Reichlin, Seymour, 1974, Neuroendocrinology, in: Textbook of Endocrinology (Robert H. Williams, ed.), pp. 774–831, W. B. Saunders, Philadelphia.Google Scholar
  135. Rubin, R. T., and Mandell, A. J., 1966, Adrenal cortical activity in pathological emotional states: A review. Am. J. Psychiatry123:387–400.PubMedGoogle Scholar
  136. Rubin, R. T., Mandell, A. J., and Crandall, P. H., 1966. Corticosteroid responses to limbic stimulation in man: Localization of stimulus sites, Science153:767–768.PubMedGoogle Scholar
  137. Rusak, B., and Zucker, I., 1975, Biological rhythms and animal behavior, Annu. Rev. Psychol.26:137–171.PubMedGoogle Scholar
  138. Ryan, R. J., Swanson, D. W., Faiman, C., Mayberry, W. E., and Spandoni, A. J., 1970, Effects of convulsive electroshock on serum concentrations of follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone and growth hormone in man, J. Clin. Endocrinol. Metab.30:51–58.PubMedGoogle Scholar
  139. Saarima, H. A., Sourander, C., and Rinne, U. K., 1963, The effect of chlorpromazine on the secretion of corticotropin in psychiatric patients examined by the metapiron test, Acta Psychiatr. Scand.169(suppl.):362–365.Google Scholar
  140. Sachar, E. J., 1975a, Hormonal changes in stress and mental illness, Hosp. Pract.10:49–55.Google Scholar
  141. Sachar, E. J., 1975b Twenty-four Cortisol secretory patterns in depressed and manic patients, in: Hormones, Homeostasis and the Brain (W. Gispen, ed.), pp. 81–91, Elsevier, New York.Google Scholar
  142. Sachar, E. J., 1975c, Neuroendocrine dysfunction in depressive illness, Annu. Rev. Med.27:389–396.Google Scholar
  143. Sachar, E. J., 1975d, Psychiatric disturbances associated with endocrine disorders, in: American Handbook of Psychiatry, Vol. 4 (Morton Reiser, ed.), pp. 299–313, Basic Books, New York.Google Scholar
  144. Sachar, E. J., Hellman, L., Fukushima, D. K., and Gallagher, T. F., 1970a, Cortisol production in depressive illness, Arch. Gen. Psychiatry23:289–298.PubMedGoogle Scholar
  145. Sachar, E. J., Kanter, S. S., Buie, D., Engle, R., and Mehlman, R., 1970b, Psychoendocri-nology of ego disintegration, A m. J. Psychiatry126:1067–1078.Google Scholar
  146. Sachar, E. J., Hellman, L., Roffwarg, H., Halpern, F. S., Fukushima, D. K., and Gallagher, T. F., 1973, Disrupted 24-hour patterns of Cortisol secretion in psychotic depression, Arch. Gen. Psychiatry28:19–24.PubMedGoogle Scholar
  147. Saffron, M., Schally, A. V., and Benfey, B. G., 1955, Stimulation of the release of corticotropin from the adenohypophysis by a neurohypophysial factor, Endocrinology57:439–444.Google Scholar
  148. Saleman, M., Peck, L., and Egdahl, R. H., 1970, Effect of acute and prolonged electrical stimulation of the amygdala of the dog upon peripheral plasma concentrations of corticosteroids, Neuroendocrinology6:361–367.Google Scholar
  149. Sayers, G., and Travis, P. H., 1970, Adrenocorticotropic hormone, adrenocortical steroids and their synthetic analogs, in: Pharmacological Basis of Therapeutics (L. Goodman and A. Gilman, eds.), pp. 1604–1642, Macmillan, New York.Google Scholar
  150. Scapagnini, U., 1973, Effects of drugs acting on brain monoamines and control of adrenocortical function, in: Endocrinology (R. O. Scow, ed.), pp. 125–130, Excerpta Medica, Amsterdam.Google Scholar
  151. Scapagnini, U., Van Loon, G. R., Moberg, C. P., and Ganong, W. F., 1970, Effect of alpha-methyl-para-tyrosine on the circadian variation of plasma corticosterone in rats, Eur. J. Pharmacol.11:266–268.PubMedGoogle Scholar
  152. Scapagnini, U., Moberg, G. P., Van Loon, G. R., De Groot, J., and Ganong, W. F., 1971, Relation of brain 5-hydroxytryptamine content to the diurnal variation in plasma corticosterone in the rat, Neuroendocrinology7:90–96.PubMedGoogle Scholar
  153. Schally, A. V., Akimura, A., and Kastin, A., 1973, Hypothalamic regulatory hormones, Science179:341–350.PubMedGoogle Scholar
  154. Schildkraut, J. J., 1965, The catacholamine hypothesis of affective disorders: A review of the supporting evidence, Am. J. Psychiatry122:509–522.PubMedGoogle Scholar
  155. Selye, H., 1950, Stress and the general adaptation syndrome, Br. Med. J.2:1383–1392.Google Scholar
  156. Shader, R. I., and Di Mascio, A., 1968, Psychotropic drugs: A review of endocrine and metabolic effects, in: Psychopharmacology, A Review of Progress 1957–1967 (D. H. Efron, ed.), pp. 1093–1100, U.S. Government Printing Office, Washington, D.C.Google Scholar
  157. Shader, R. I., Giller, D. R., and Di Mascio, A., 1970, Hypothalamic-pituitary-adrenal axis, in: Psychotropic Drug Side Effects (Richard I. Shader and Alberto Di Mascio, eds.), pp. 16–25, Williams and Wilkins, Baltimore.Google Scholar
  158. Sherman, L., Kim, S., Benjamin, F., and Kolodny, H. D. C., 1971, Effects of chlorproma-zine on serum growth hormone concentration in man, N. Engl. J. Med.284:72–74.PubMedGoogle Scholar
  159. Shopsin, B., and Gershon, S., 1971, Plasma Cortisol response to dexamethasone suppression in depressed and control subjects, Arch. Gen. Psychiatry24:320–326.PubMedGoogle Scholar
  160. Shute, C. C. D., and Lewis, P. R., 1966, Cholinergic and monoaminergic pathways in the hypothalamus, Br. Med. Bull.22:221–226.PubMedGoogle Scholar
  161. Siegel, G. J., and Eisenman, J. S., 1972, Hypothalamic-pituitary regulation, in: Basic Neurochemistry (R. W. Albers, G. J. Siegel, R. Katzman, and B. W. Agranoff, eds.), pp. 341–363, Little, Brown, Boston.Google Scholar
  162. Siegler, D. I. M., 1970, Idiopathic Addison’s disease presenting with hypercalcemia, Br. Med. J.2:522.PubMedGoogle Scholar
  163. Simon, M. L., and George, R., 1975, Diurnal variations in plasma corticosterone and growth hormone as correlated with regional variations in norepinephrine, dopamine, and serotonin content of rat brain, Neuroendocrinology17:125–138.PubMedGoogle Scholar
  164. Spillane, J. D., 1951, Nervous and mental disorders in Cushing’s syndrome, Brain74:72–94.PubMedGoogle Scholar
  165. Starr, A. M., 1952, Personality changes in Cushing’s syndrome, J. Clin. Endocrinol.12:502–505.Google Scholar
  166. Stefanini, M., Roy, C. A., Zannos, L., and Dameshek, W., 1950, Therapeutic effect of pituitary adrenocorticotropic hormone (ACTH) in a case of Henoch-Schonlein vascular (anaphylactoid) purpura, J. Am. Med. Assoc.144:1372–1374.PubMedGoogle Scholar
  167. Stokes, P., 1972, Studies on the control of adrenocortical function in depression, in: Recent Advances in the Psychobiology of the Depressive Illnesses (T. A. Williams, M. M. Katz, and J. A. Shield, Jr., eds.), pp. 199–220, U.S. Government Printing Office, Washington, D.C.Google Scholar
  168. Stoll, W. A., 1953, Die Psychiatrie des Morbus Addison, Thieme, Stuttgart.Google Scholar
  169. Telegdy, G., and Vermes, L., 1973, The role of serotonin in the regulation of the hypophysis-adrenal system, in: Brain-Pituitary-Adrenal Interrelationships (A. Brodish and E. S. Redgate, eds.), pp. 332–333, Karger, Basel.Google Scholar
  170. Trethowan, W. H., and Cobb, S., 1952, Neuropsychiatric aspects of Cushing’s syndrome, Arch. Neurol. Psychiatry67:283–309.Google Scholar
  171. Ulrich, A., Yuwiler, A., and Geller, E., 1975, Effects of hydrocortisone on biogenic amine levels in the hypothalamus, Neuroendocrinology19:259–268.PubMedGoogle Scholar
  172. Van Loon, G. R., 1973, Brain catecholamines and ACTH secretion, in: Frontiers in Neuroendocrinology (F. W. Ganong and L. Martini, eds.), pp. 209–247, Oxford University Press, New York.Google Scholar
  173. Van Loon, G. R., and Ganong, W. F., 1969, Effect of drugs which alter catecholamine metabolism on the inhibition of stress-induced ACTH secretion produced by L-dopa, Physiologist12:381.Google Scholar
  174. Van Loon, G. R., Hilger, L., Cohen, R., and Ganong, W. F., 1969, Evidence for a hypothalamic adrenergic system that inhibits ACTH secretion in the dog, Fed. Proc.28:438.Google Scholar
  175. Verghese, A., Mathew, J., Matha, G., Kothoor, A., Saxena, B., and Kashy, T., 1973, Plasma Cortisol in depressive illness, Indian J. Psychiatry15:72–79.Google Scholar
  176. Vernikos-Danellis, J., Berger, P., and Barchas, J. D., 1973, Brain serotonin and pituitary-adrenal function, Prog. Brain Res.39:301–308.PubMedGoogle Scholar
  177. Weitzman, E. D., Fukushima, D. K., Nogire, C., Roffwarg, H., Gallagher, T. F., and Hellman, L., 1971, Twenty-four hour pattern of the episodic secretion of Cortisol in normal subjects, J. Clin. Endocrinol.33:14–22.Google Scholar
  178. Weitzman, E. D., Boyar, R. M., Kapen, S., and Hellman, L., 1975, The relationship of sleep and sleep stages to neuroendocrine secretion and biological rhythms in man, in: Recent Progress in Hormone Research, Vol. 31 (R. Greep, ed.), pp. 399–440, Academic Press, New York.Google Scholar
  179. Williams, R. H., 1970, Metabolism and mentation, J. Clin. Endocrinol.31:461–479.Google Scholar
  180. Woodbury, D. M., 1958, Relation between the adrenal cortex and the central nervous sytem, Pharmacol. Rev.10:275–357.PubMedGoogle Scholar
  181. Woodbury, D. M., and Vernadakas, A., 1966, Effects of steroids on the central nervous system, Methods Horm. Res.5:1–57.Google Scholar
  182. Wurtman, R. J., 1971, Brain monoamines and endocrine function, Neurosci. Res. Progr. Bull.9:214–217.Google Scholar
  183. Wurtman, R. J., and Fernstrom, J. D., 1976, Neuroendocrine effects of psychotropic drugs, in: Hormones, Behavior and Psychopathology (E. J. Sachar, ed.), pp. 145–151, Raven Press, New York.Google Scholar
  184. Yalow, R. S., Varsano-Aharon, N., Echemendia, E., and Berson, S. A., 1969, HGH and ACTH secretory responses to stress, Horm. Metab. Res.1:3–8.PubMedGoogle Scholar
  185. Zimmerman, E., Carmel, P. W., Husain, M. K., Ferin, M., Tannenbaum, M., Frantz, A., and Robinson, A., 1973, Vasopressin and Neurophysin: High concentrations in monkey hypophyseal portal blood, Science182:925–927.PubMedGoogle Scholar
  186. Zumoff, B., Fukushima, D. F., Weitzman, E. D., Kream, J., and Hellman, L., 1974, The sex differences in plasma Cortisol concentration in man, J. Clin. Endocrinol. Metab.39:805–808.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • William T. CarpenterJr.
    • 1
  • Peter H. Gruen
    • 2
  1. 1.Maryland Psychiatric Research Center, and Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of PsychiatryBronx Municipal Hospital CenterBronxUSA

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