Drugs of Abuse pp 319-371 | Cite as

Cannabis: Structure-Activity Relationships

  • R. Duane Sofia
Part of the Handbook of Psychopharmacology book series (HBKPS)


Cannabis sativa or marihuana most likely is one of man’s oldest and most widely used drugs (Mikuriya, 1969). The earliest record of its use and description was in China in 2737 b.c. Its use as an intoxicant spread to India and North Africa and from there to Europe, probably as a result of the expedition of Napoleon during his Egyptian campaign around 1800. In the Western Hemisphere marihuana has been known for centuries in South and Central America, but it was not used in the United States to any significant degree until the early 1900s.


Analgesic Activity Anticonvulsant Activity Paradoxical Sleep Spontaneous Locomotor Activity Audiogenic Seizure 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • R. Duane Sofia
    • 1
  1. 1.Biological ResearchWallace LaboratoriesCranburyUSA

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