Analgesics and their Antagonists: Structure-Activity Relationships

  • Arthur E. Jacobson
Part of the Handbook of Psychopharmacology book series (HBKPS)


Qualitative theories that attempt to relate molecular structure to analgesic or narcotic antagonist activity have given the contemporary medicinal chemist only slight ability to predict, a priori, the analgesic potencies of compounds. The discovery of new types of analgesics by the medicinal chemist has often been serendipitous (Eddy and May, 1973). Other new analgesics were designed through clever rationalizations based on natural products or previously synthesized similar drugs.


Analgesic Activity Opiate Receptor Narcotic Analgesic Analgesic Potency Narcotic Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Arthur E. Jacobson
    • 1
  1. 1.Medicinal Chemistry Section, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive DiseasesNational Institutes of HealthBethesdaUSA

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