The Psychopharmacology of Feeding

  • Bartley G. Hoebel
Part of the Handbook of Psychopharmacology book series (HBKPS)


Studies of behavioral neurochemistry have revolutionized research on feeding. The catalyst was Grossman’s (1960) discovery that norepinephrine injected directly into the hypothalamus via a cannula selectively induced feeding behavior in the rat. Then Ungerstedt (1970) showed that depletion of dopamine by intracerebral injection of a selective neurotoxin could mimic part of the classical, lateral hypothalamic, starvation syndrome. The advent of a simple technique for injecting drugs into the brain through implanted cannulas and the realization that the local application of drugs could have meaningful behavioral effects has precipitated a great change in the neuroscientist’s approach and thinking. Studies of feeding have been at the forefront of this change.


Anorexia Nervosa Lateral Hypothalamus Dopamine Depletion Alpha Blocker Hypothalamic Lesion 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Bartley G. Hoebel
    • 1
  1. 1.Department of PsychologyPrinceton UniversityPrincetonUSA

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