The Role of Prefrontal Cortex in Intracranial Self-Stimulation

A Case History of Anatomical Localization of Motivational Substrates
  • Aryeh Routtenberg
  • Rebecca Santos-Anderson
Part of the Handbook of Psychopharmacology book series (HBKPS)


Intracranial self-stimulation remains enigmatic. There is one view that its demonstration lies at the heart of our understanding of the brain substrates of behavior, and there is another, but quite opposite view, that suggests that it is to be dismissed as an artifact, and cannot provide any meaningful insights. Regardless of viewpoint, it does seem refractory to study with the logical building-block approach used in a variety of scientific lines of research. Perhaps the problem is that one does not know the appropriate initiation point. As a consequence, a variety of investigators have begun at quite different starting points.


Prefrontal Cortex Frontal Cortex Locus Coeruleus Fiber Pathway Lateral Hypothalamus 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Aryeh Routtenberg
    • 1
  • Rebecca Santos-Anderson
    • 1
  1. 1.Cresap Neuroscience LaboratoryNorthwestern UniversityEvanstonUSA

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