Excitatory Amino Acid Receptors in the Central Nervous System
Speculation on the possible role played by the physiologically occurring dicarboxylic amino acids L-aspartate and L-glutamate has continued from the time that Hayashi (1954) first described the marked excitatory action of the latter compound on the general electrical activity of the cerebral cortex. Thereafter, the potent effect of these substances on single neurons of the spinal cord was demonstrated (Curtis et al., 1960), and similar studies have now been made of cells in many other parts of the central nervous system (for references, see Johnson, 1972). Although an occasional apparently anomalous result has been reported (McLennan, 1971), it appears that all or almost all neurons of the central nervous system can be depolarized and excited by glutamate or aspartate introduced into their immediate extracellular environments.
KeywordsGlutamate Uptake Acidic Amino Acid Spinal Neurone Excitatory Amino Acid Receptor Cuneate Nucleus
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- Boakes, R. J., Bradley, P. B., Briggs, I., and Dray, A., 1970, Antagonism of 5-hydroxytryptamine by LSD 25 in the central nervous system: A possible neuronal basis for the actions of LSD 25, Brit. J. Pharmacol. 40:202–218.Google Scholar
- Clarke, G., Hill, R. G., and Simmonds, M. A., 1973, Microiontophoretic release of drugs from micropipettes: Use of 24Na as a model, Brit. J. Pharmacol. 48:156–161.Google Scholar
- Curtis, D. R., 1964, Microelectrophoresis, in: Physical Techniques in Biological Research, Vol. 5, Part A (W. L. Nastuk, ed.), pp. 144–190, Academic Press, New York.Google Scholar
- Dudar, J. D., 1972, Glutamic acid sensitivity of hippocampal pyramidal cell dendrites, Acta Physiol. Scand. 84:C6.Google Scholar
- Duggan, A. W., 1971, Amino acids as transmitters, Ph.D. thesis, Australian National University.Google Scholar
- Galindo, A., 1969, Effects of procaine, pentobarbital and halothane on synaptic transmission in the central nervous system, J. Pharmacol. 169:185–195.Google Scholar
- Hayashi, T., 1959, Neurophysiology and Neurochemistry of Convulsion, Dainihon-Tosho, Tokyo.Google Scholar
- Jack, J. J. B., Miller, S., Porter, R., and Redman, S. J., 1970, in: Excitatory Synaptic Mechanisms (P. Andersen and J. K. S. Jansen, eds.), pp. 199–205, Universitetsforlaget, Oslo.Google Scholar
- Krnjević, K., 1971, Microiontophoresis, in: Methods of Neurochemistry (R. Fried, ed.), pp. 129–172, Marcel Dekker, New York.Google Scholar
- Morgan, R., Vrbovä, G., and Wolstencroft, J. H., 1972, Correlation between the retinal input to lateral geniculate neurones and their relative response to glutamate and aspartate, J.Physiol. 224:41–42P.Google Scholar