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Transynaptic Regulation of Neuronal Enzyme Synthesis

  • Hans Thoenen
Part of the Handbook of Psychopharmacology book series (HBKPS, volume 3)

Abstract

Until fairly recently, the main emphasis in neurobiological research was concentrated on morphological features of neuronal systems and electrical phenomena of neuronal activity. Biochemical investigations were mainly confined to static-descriptive approaches, particularly those concerning the macromolecular constituents of neurons. The neurons were thought to act as stable electronic components designed to generate, transmit, and modulate electrical impulses. This attitude regarding the interpretation of neuronal activity and neuronal interaction prompted a comparison of neuronal systems with computers. However, the basic difference between a computer and an integrated neuronal system such as the mammalian brain is the “plasticity” of the latter, i.e., its capability to adapt to changing functional requirements (Giacobini, 1970). Although the general arrangement of neurons and their “wiring” are genetically determined, there is a relatively wide range of variability available for modifications according to the use of the neuronal pathways and connections. The ability of neurons to undergo “plastic reactions” is reflected not only by biochemically detectable changes in their macromolecular composition but even changes in their morphology (Cragg, 1972; Horn et al., 1973). These function-dependent biochemical and structural changes do not appear to have an analogue in contemporary electronic systems.

Keywords

Tyrosine Hydroxylase Adrenal Medulla Sympathetic Ganglion Superior Cervical Ganglion Choline Acetyltransferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ames, B. N., and Martin, R. G., 1964, Biochemical aspects of genetics: The operon, Ann. Rev. Biochem. 33: 235–253.PubMedGoogle Scholar
  2. Angeletti, P. U., and Levi-Montalcini, R., 1970, Sympathetic nerve cell destruction in newborn mammals by 6-hydroxydopamine, Proc. Natl. Acad. Sci. 65: 114–121.PubMedGoogle Scholar
  3. Axelrod, J., 1971, Noradrenaline: Fate and control of its biosynthesis, Science 173:598–606. Axelrod, J., 1972, Dopamine β-hydroxylase: Regulation of its synthesis and release from nerve terminals, Pharmacol. Rev. 24: 233–243.Google Scholar
  4. Azmitia, E. C., and McEwen, B. S., 1969, Corticosterone regulation of tryptophan hydroxylase in midbrain of the rat, Science 166: 1274–1276.PubMedGoogle Scholar
  5. Azmitia, E. C., Hess, P., and Reis, D., 1970, Tryptophan hydroxylase changes in midbrain of the rat after chronic morphine administration, Life Sci. 9: 633–637.Google Scholar
  6. Berry, R. W., 1969, Ribonucleic acid metabolism of a single neuron: Correlation with electrical activity, Science 166: 1021–1023.PubMedGoogle Scholar
  7. Bhagat, B., and Rana, M. W., 1971, Effect of chronic administration of nicotine on the concentrations of adrenal enzymes involved in the synthesis and metabolism of adrenaline, Brit. J. Pharmacol. 43: 250–251.Google Scholar
  8. Black, I. B., 1973, Development of adrenergic neurons in vivo: Inhibition by ganglionic blockade, J. Neurochem. 20: 1265–1267.PubMedGoogle Scholar
  9. Black, I. B., Bloom, F. E., Hendry, I. A., and Iversen, L. L., 197 la, Growth and development of a sympathetic ganglion: Maturation of transmitter enzymes and synapse formation in the mouse superior cervical ganglion, J. Physiol. 215: 23P–24 P.Google Scholar
  10. Black, I. B., Hendry, I. A., and Iversen, L. L., 19716, Trans-synaptic regulation of growth and development of adrenergic neurones in a mouse sympathetic ganglion, Brain Res. 34: 229–240.Google Scholar
  11. Black, I. B., Hendry, I. A., and Iversen, L. L., 1971c, Differences in the regulation of tyrosine hydroxylase and dopa decarboxylase in sympathetic ganglia and adrenals, Nature New Biol. 231: 27–29.PubMedGoogle Scholar
  12. Black, I. B., Hendry, I. A., and Iversen, L. L., 1972a, The role of post-synaptic neurones in the biochemical maturation of presynaptic cholinergic nerve terminals in a mouse sympathetic ganglion, J. Physiol. 221: 149–159.PubMedGoogle Scholar
  13. Black, I. B., Hendry, I. A., and Iversen, L. L., 19726, Effects of surgical decentralization and nerve growth factor on the maturation of adrenergic neurons in a mouse sympathetic ganglion, J. Neurochem. 19: 1367–1377.Google Scholar
  14. Brimijoin, S., 1972, Transport and turnover of dopaminergic β-hydroxylase (EC 1.14.2.1) in sympathetic nerves of the rat, J. Neurochem. 19: 2183–2193.PubMedGoogle Scholar
  15. Brown, G. L., and Pascoe, J. E., 1954, The effect of degeneration of ganglionic axons on transmission through the ganglion, J. Physiol. 123: 565–573.PubMedGoogle Scholar
  16. Burt, D. R., and Larrabee, M. G., 1973, Subcellular site of the phosphatidylinositol effect: Distribution on density gradients of labelled lipids from resting and active sympathetic ganglia of the rat, J. Neurochem. 21: 255–272.PubMedGoogle Scholar
  17. Ciaranello, R. D., and Black, I. B., 1971, Kinetics of the glucocorticoid-mediated induction of phenylethanolamine iV-methyltransferase in the hypophysectomized rat, Biochem. Pharmacol. 20: 3529–3532.Google Scholar
  18. Ciaranello, R. D., Jacobowitz, D., and Axelrod, J., 1973, Effect of dexamethasone on phenylethanolamine N-methyltransferase in chromaffin tissue of the neonatal rat, J. Neurochem. 20: 799–805.PubMedGoogle Scholar
  19. Costa, E., and Guidotti, A., 1973, The role of 3’,5’-cyclic adenosine monophosphate in the regulation of adrenal medullary function, in: New Concepts in Neurotransmitter Regulation ( A. J. Mandell, ed.), pp. 135–152, Plenum, New York.Google Scholar
  20. Coyle, J. T., and Wooten, G. F., 1972, Rapid axonal transport of tyrosine hydroxylase and dopamine β-hydroxylase, Brain Res. 44: 701–704.PubMedGoogle Scholar
  21. Cragg, B. G., 1970, What is the signal for chromatolysis? Brain Res. 23: 1–21.PubMedGoogle Scholar
  22. Cragg, B. G., 1972, Plasticity of synapses, in: Structure and Function of Nervous Tissues, Vol. 4 ( G. H. Bourne, ed.), pp. 1–60, Academic Press, New York.Google Scholar
  23. Dairman, W., and Udenfriend, S., 1970, Increased conversion of tyrosine to catecholamines in intact rat following elevation of tissue tyrosine hydroxylase levels by administered phenoxybenzamine, Mol. Pharmacol. 6: 350–356.Google Scholar
  24. Dairman, W., Gordon, R., Spector, S., Sjoerdsma, A., and Udenfriend, S., 1968, Increased synthesis of catecholamines in the intact rat following administration of a-adrenergic blocking agents, Mol. Pharmacol. 4: 457–464.Google Scholar
  25. Dairman, W., Geffen, L., and Marchelle, M., 1973, Axoplasmic transport of aromatic I-amino acid decarboxylase (EC 4.1.1.26) and dopamine β-hydroxylase (EC 1.14.2.1) in rat sciatic nerve, J. Neurochem. 20: 1617–1623.PubMedGoogle Scholar
  26. Davison, P. F., 1970, Axoplasmic transport: Physical and chemical aspects, in: The Neurosci- ences: Second Study Program ( F. O. Scmitt, ed.), pp. 851–858, Rockefeller University Press, New York.Google Scholar
  27. Deguchi, T., 1973, Role of beta adrenergic receptor in the elevation of adenosine cyclic 3’,5’–monophosphate and induction of serotonin N-acetyltransferase in rat pineal glands, Mol. Pharmacol. 9: 184–190.Google Scholar
  28. Ebel, A., Mack, G., Stefanovic, V., and Mandel, P., 1973, Activity of choline acetyltransferase and acetylcholinesterase in the amygdala of spontaneous mouse-killer rats and in rats after olfactory lobe removal. Brain Res. 57: 248–251.PubMedGoogle Scholar
  29. Eichelman, B., Thoa, N. B., Bugbee, N. M., and Ng, K. Y., 1972, Brain amine and adrenal enzyme levels in agressive, bulbectomized rats, Physiol. Behav. 9: 483–485.Google Scholar
  30. Fahn, S., Rodman, J. S., and Cote, L. J., 1969, Association of tyrosine hydroxylase with synaptic vesicles in bovine caudate nucleus, J. Neurochem. 16: 1293–1300.PubMedGoogle Scholar
  31. Gal, E. M., and Marshall, F. D., Jr., 1964, The hydroxylation of tryptophan by pigeon brain in vivo, Prog. Brain Res. 8: 56–60.Google Scholar
  32. Gal, E. M., Heater, R. D., and Millard, S. A., 1968, Studies on metabolism of 5-hydroxytryptamine (serotonin). VI. Hydroxylation and amines in cold-stressed reser- pinized rats, Proc. Soc. Exp. Biol. 128: 412–415.PubMedGoogle Scholar
  33. Geffen, L. B., and Livett, B. G., 1971, Synaptic vesicles in sympathetic neurons, Physiol. Rev. 51: 98–157.PubMedGoogle Scholar
  34. Geffen, L. B., and Rush, R. A., 1968, Transport of noradrenaline in sympathetic nerves and effect of nerve impulses on its contribution to transmitter stores, J. Neurochem. 15: 925–930.PubMedGoogle Scholar
  35. George, W. J., Wilkerson, R. D., and Kadowitz, Ph. J., 1973, Influence of acetylcholine on contractile force and cyclic nucleotide levels in the isolated perfused rat heart, f. Pharmacol. Exp. Ther. 184: 228–235.Google Scholar
  36. Gewirtz, G. P., and Kopin, I. J., 1970, Release of dopamine β-hydroxylase with norepinephrine during cat splenic nerve stimulation, Nature 227: 406–407.PubMedGoogle Scholar
  37. Giacobini, E., 1970, Biochemistry of simple plasticity studied in single neurons, in: Advances in Biochemical Psychopharmacology, Vol. 2 ( E. Costa and E. Giacobini, eds.), pp. 9–64, Raven Press, New York.Google Scholar
  38. Gisiger, V., 1971, Triggering of RNA synthesis by acetylcholine stimulation of the post-synaptic membrane in a mammalian sympathetic ganglion, Brain Res. 33: 139–146.PubMedGoogle Scholar
  39. Gisiger, V., and Guide-Huguenin, A. C., 1969, Effect of preganglionic stimulation upon RNA synthesis in the isolated sympathetic ganglion of the rat, Prog. Brain Res. 31: 125–129.Google Scholar
  40. Goldberg, A. M., and Welch, B. L., 1972, Adaptation of the adrenal medulla: Sustained increase in choline acetyltransferase by psychosocial stimulation, Science 178: 319–320.PubMedGoogle Scholar
  41. Goodman, R., Oesch, F., and Thoenen, H., 1974, Changes in enzyme patterns produced by potassium depolarization and dibutyryl cyclic AMP in organ culture of sympathetic ganglia, J. Neurochem. 23: 369–378.PubMedGoogle Scholar
  42. Grahame-Smith, D. G., 1964, Tryptophan hydroxylation in brain, Biochem. Biophys. Res. Commun. 16: 586–592.Google Scholar
  43. Greengard, P., and McAfee, D. A., 1972, Adenosine 3’,5’-cyclic monophosphate as a mediator in the action of neurohumoral agents, Biochem. Soc. Symp. 36: 87–102.Google Scholar
  44. Guidotti, A., and Costa, E., 1973, Involvement of adenosine 3’,5’-monophosphate in the activation of tyrosine hydroxylase elicited by drugs, Science 179: 902–904.PubMedGoogle Scholar
  45. Guidotti, A., Mao, C. C., and Costa, E., 1974, Trans-synaptic regulation of tyrosine hydroxylase in adrenal medulla: Possible role of cyclic nucleotides, in: Frontiers in Catecholamine Research, III International Catecholamine Symposium, pp. 231–236, Perga- mon Press, New York.Google Scholar
  46. Hendry, I. A., 1973, Trans-synaptic regulation of tyrosine hydroxylase activity in a developing mouse sympathetic ganglion: Effects of nerve growth factor (NGF), NGF-antiserum and pempidine, Brain Res. 56: 313–320.PubMedGoogle Scholar
  47. Hendry, I. A., Iversen, L. L., and Black, I. B., 1973, A comparison of the neural regulation of tyrosine hydroxylase activity in sympathetic ganglia of adult mice and rats, J. Neurochem. 20: 1683–1689.PubMedGoogle Scholar
  48. Horn, G., Rose, S. P. R., and Bateson, P. P. G., 1973, Experience and plasticity in the central nervous system, Science 181: 506–514.PubMedGoogle Scholar
  49. Joh, T. H., Gegliman, C., and Reis, D. J., 1973, Immunochemical demonstration of increased accumulation of tyrosine hydroxylase protein in sympathetic ganglia and adrenal medulla elicited by reserpine, Proc. Natl. Acad. Sci. 70: 2767–2771.PubMedGoogle Scholar
  50. Karlsson, J. O., and Sjostrand, J., 1972, Axonal transport of proteins in retinal ganglion cells: Characterization of the transport to the superior colliculus, Brain Res. 47: 185–194.PubMedGoogle Scholar
  51. Keen, P., and McLean, W. G., 1972, Effect of dibutyryl cyclic AMP on levels of dopamine β-hydroxylase in isolated superior cervical ganglia, Naunyn-Schmiedebergs Arch. Pharmacol. 275: 465–469.Google Scholar
  52. Kernell, D., and Peterson, R. P., 1970, The effect of spike activity versus synaptic activation on the metabolism of ribonucleic acid in a mulluscian giant neurone, J. Neurochem. 17: 1087–1094.PubMedGoogle Scholar
  53. Kety, S. S., 1970, The biogenic amines in the central nervous system: Their possible roles in arousal, emotion and learning, in: The Neurosciences ( F. O. Schmitt, ed.), pp. 1324–1335, Rockefeller University Press, New York.Google Scholar
  54. Kopin, I. J., and Silberstein, S. D., 1972, Axons of sympathetic neurons: Transport of enzymes in vivo and properties of axonal sprouts in vitro, Pharmacol. Rev. 24: 245–254.Google Scholar
  55. Kreutzberg, G. W., and Schubert, P., 1971, Changes in axonal flow during regeneration of mammalian motor nerves, Acta neuropathol. Suppl. 5: 70–75.Google Scholar
  56. Kuczenski, R. T., and Mandell, A. J., 1972, Allosteric activation of hypothalamic tyrosine hydroxylase by ions and sulfate mucopolysaccharides, J. Neurochem. 19: 131–137.PubMedGoogle Scholar
  57. Kuczenski, R. T., and Mandell, A. J., 1972, Regulatory properties of soluble and particulate rat brain tyrosine hydroxylase, J. Biol. Chem. 247: 3114–3122.PubMedGoogle Scholar
  58. Kvetnansky, R., Weise, V. K., and Kopin, I. J., 1970a, Elevation of adrenal tyrosine hydroxylase and phenylethanolamine N-methyltransferase by repeated immobilization of rats, Endocrinology 87: 744–749.PubMedGoogle Scholar
  59. Kvetnansky, R., Gewirtz, G. P., Weise, V. K., and Kopin, I. J., 19706, Effect of hypophysec- tomy on immobilization-induced elevation of tyrosine hydroxylase and phenylethanolamine-JV-methyl transferase in the rat adrenal, Endocrinology 87: 1323–1329.Google Scholar
  60. Kvetnansky, R., Gewirtz, G. P., Weise, V. K., and Kopin, I. J., 1971, Enhanced synthesis of adrenal dopamine β-hydroxylase induced by repeated immobilization in rats, Mol. Pharmacol. 7: 81–86.Google Scholar
  61. Laduron, P. and Belpaire, F., 1968, Transport of noradrenaline and dopamine β-hydroxylase in sympathetic nerves, Life Sci. 7: 1–7.PubMedGoogle Scholar
  62. Lamprecht, F., Eichelman, B., Thoa, N. B., Williams, R. B., and Kopin, I. J., 1972, Rat fighting behavior: Serum dopamine jS-hydroxylase and hypothalamic tyrosine hydroxylase, Science 177: 1214–1215.PubMedGoogle Scholar
  63. Larrabee, M. G., 1969, Metabolic effects of nerve impulses and nerve-growth factor in sympathetic ganglia, Prog. Brain Res. 31: 95–110.Google Scholar
  64. Lee, T. P., Kuo, J. F., and Greengard, P., 1972, Role of muscarinic cholinergic receptors in regulation of guanosine 3’,5’-cyclic monophosphate content in mammalian brain, heart, muscle and intestinal smooth muscle, Proc. Natl. Acad. Sci. 69: 3287–3291.PubMedGoogle Scholar
  65. Lerner, R. A., McCornahey, P. J., Jansen, I., and Dixon, F. J., 1972, Synthesis of plasma membrane-associated and secretory immunoglobulin in diploid lymphocytes, J. Exp. Med. 135: 136–149.PubMedGoogle Scholar
  66. Levitt, M., Spector, S., Sjoerdsma, A., and Udenfriend, S., 1965, Elucidation of the rate-limiting step in noradrenaline biosynthesis in the perfused guinea-pig heart, J. Pharmacol. Exp. Ther. 148: 1–8.PubMedGoogle Scholar
  67. Mackay, A. V. P., 1974, The long-term regulation of tyrosine hydroxylase activity in cultured sympathetic ganglia: Role of ganglionic noradrenaline content. Brit. J. Pharmacol., 51: 509–520.Google Scholar
  68. Mackay, A. V. P., and Iversen, L. L., 1972a, Trans-synaptic regulation of tyrosine hydroxylase activity in adrenergic neurons: Effect of potassium concentration on cultured sympathetic ganglia, Naunyn-Schmiedebergs Arch. Pharmacol. 272: 225–229.Google Scholar
  69. Mackay, A. V. P., and Iversen, L. L., 19726, Increased tyrosine hydroxylase activity of sympathetic ganglia cultured in the presence of dibutyryl cyclic AMP, Brain Res. 48: 424–426.Google Scholar
  70. Maengwyn-Davies, G. D., Johnson, D. G., Thoa, N. B., Weise, V. K., and Kopin, I. J., 1973, Influence of isolation and of fighting on adrenal tyrosine hydroxylase and phenylethanolamine-N-methyl transferase activity in three strains of mice, Psychophar- macology 28: 339–350.Google Scholar
  71. Mandell, A. J., 1973, Redundant macromolecular mechanisms in central synaptic regulation, in: New Concepts in Neurotransmitter Regulation ( A. J. Mandell, ed.), pp. 259–277, Plenum, New York.Google Scholar
  72. Mandell, A. J., and Morgan, M., 1970, Amphetamine induced increase in tyrosine hydroxyl-ase activity, Nature 227: 75–76.PubMedGoogle Scholar
  73. Mandell, A. J., Knopp, S., Kuczenski, R. T., and Segal, D. S., 1972a, A methamphetamine induced shift in the physical state of rat caudate tyrosine hydroxylase, Biochem. Pharmacol. 2l: 2737–2750.Google Scholar
  74. Mandell, A. J., Segal, D. S., Kuczenski, R. T., and Knapp, S., 19726, Some macromolecular mechanisms in CNS neurotransmitter pharmacology and their psychobiological organiza-tion, in: The Chemistry of Mood, Motivation and Memory (J. McGaugh, ed.), pp. 105–148, Plenum Press, New York.Google Scholar
  75. Martz, E., and Steinberg, M. S., 1973, Contact inhibition of what? An analytical review, J. Cell Physiol. 81: 25–38.PubMedGoogle Scholar
  76. McAfee, D. A., and Greengard, P., 1972, Adenosine 3’,5’-monophosphate: Electrophysiological evidence for a role in synaptic transmission, Science 178: 310–312.PubMedGoogle Scholar
  77. McAfee, D. A., Schorderet, M.,and Greengard, P., 1971, Adenosine 3’,5’-monophosphatein nervous tissue: Increase associated with synaptic transmission, Science 171: 1156–1158.PubMedGoogle Scholar
  78. Meek, J. L., and Neff, N. H., 1972, Tryptophan 5-hydroxylase: Approximation of half-life and rate of axonal transport, J. Neurochem. 19: 1519–1525.PubMedGoogle Scholar
  79. Molinoff, P. B., and Axelrod, J., 1971, Biochemistry of catecholamines, Ann. Rev. Biochem. 40: 465–500.PubMedGoogle Scholar
  80. Molinoff, P. B., Brimijoin, S., Weinshilboum, R., and Axelrod, J., 1970, Neurally mediated increase in dopamine β-hydroxylase activity, Proc. Natl. Acad. Sci. 66: 453–458.PubMedGoogle Scholar
  81. Mueller, R. A., 1971, Effect of 6-hydroxydopamine on the synthesis and turnover of catecholamines and protein in the adrenal, in: 6-Hydroxy dopamine and Catecholamine Neurons ( T. Malmfors and H. Thoenen, eds.), pp. 291–30J, North-Holland, Amsterdam.Google Scholar
  82. Mueller, R. A., Thoenen, H., and Axelrod, J., 1969a, Adrenal tyrosine hydroxylase; Compensatory increase in activity after chemical sympathectomy, Science 158: 468–469.Google Scholar
  83. Mueller, R. A., Thoenen, H.,and Axelrod, J., 19696, Increase in tyrosine hydroxylase activity after reserpine administration, J. Pharmacol. Exp. Ther. 169: 74–79.Google Scholar
  84. Mueller, R. A., Thoenen, H., and Axelrod, J., 1969c, Inhibition of trans-synaptically increased tyrosine hydroxylase activity by cycloheximide and actinomycin D, Mol. Phar-macol. 5: 463–469.Google Scholar
  85. Mueller, R. A., Thoenen, H., and Axelrod, J., 1970, Inhibition of neuronally induced tyrosine hydroxylase by nicotinic receptor blockade, Europ. J. Pharmacol. 10: 51–56.Google Scholar
  86. Mueller, R. A., Otten, U., and Thoenen, H., 1974, The role of cyclic adenosine 3’,5’- monophosphate in reserpine-initiated adrenal medullary tyrosine hydroxylase induction. J. Mol. Pharmacol. 10: 855–860.Google Scholar
  87. Musacchio, J. M., Iulou, L., Kety, S. S., and Glowinski, J., 1969, Increase in rat brain tyrosine hydroxylase activity produced by electroconvulsive shock, Proc. Natl. Acad. Sci. 63: 1117–1119.PubMedGoogle Scholar
  88. Nagatsu, T., Sudo, Y., and Nagatsu, I., 1971, Tyrosine hydroxylase in bovine caudate nucleus, J. Neurochem. 18: 2179–2189.PubMedGoogle Scholar
  89. Ochs, S., 1971, Characteristics and a model for fast axoplasmic transport in nerve, J. Neurobiol. 2: 331–345.PubMedGoogle Scholar
  90. Oesch, F., 1974, Trans-synaptic induction of choline acetyltransferase in the preganglionic neuron of the peripheral sympathetic nervous system, J. Pharmacol. Exp. Ther. 188: 439–446.PubMedGoogle Scholar
  91. Oesch, F., and Thoenen, H., 1973, Increased activity of the peripheral sympathetic nervous system: Induction of choline acetyltransferase in preganglionic cholinergic neuron, Nature 242: 536–537.PubMedGoogle Scholar
  92. Oesch, F., Otten, U., and Thoenen, H., 1973, Relationship between the rate of axoplasmic transport and subcellular distribution of enzymes involved in the synthesis of norepi-nephrine, J. Neurochem. 20: 1691–1706.PubMedGoogle Scholar
  93. Otten, U., Paravicini, U., Oesch, F., and Thoenen, H., 1973a, Time requirement for the single steps of trans-synaptic induction of tyrosine hydroxylase in the peripheral sympathe-tic nervous system, Naunyn-Schmiedebergs Arch. Pharmacol. 280: 117–127.Google Scholar
  94. Otten, U., Oesch, F., and Thoenen, H., 19736, Dissociation between changes in cyclic AMP and subsequent induction of TH in the rat superior cervical ganglion and adrenal medulla, Naunyn-Schmiedebergs Arch. Pharmacol. 280: 129–140.Google Scholar
  95. Otten, U., Mueller, R. A., Oesch, F., and Thoenen, H., 1974a, Location of an isoproterenol- responsive cyclic AMP-pool in adrenergic nerve cell bodies and its relationship to tyrosine hydroxylase induction, Proc. Natl. Acad. Sci., 71: 2217–2221.PubMedGoogle Scholar
  96. Otten, U., Mueller, R. A. and Thoenen, H., 19746, Evidence against a causal relationship between rate, extent and duration of increase in c-AMP and subsequent induction of tyrosine hydroxylase in the rat adrenal medulla. Naunyn-Schmiedebergs Arch. Pharmacol. 285: 233–242.Google Scholar
  97. Pastan, I., and Perlman, R. C., 1971, Cyclic AMP in metabolism, Nature New Biol. 229: 5–7.PubMedGoogle Scholar
  98. Patrick, R. L., and Kirshner, N., 1971 a, Effect of stimulation on levels of tyrosine hydroxylase, dopamine β-hydroxylase and catecholamine in intact and denervated rat adrenal glands, Mol. Pharmacol. 7: 87–96.Google Scholar
  99. Patrick, R. L., and Kirshner, N., 19716, Acetylcholine-induced stimulation of catecholamine recovery in denervated rat adrenals after reserpine-induced depletion, Mol. Pharmacol. 7: 389–396.Google Scholar
  100. Prasad, K. N., Mandel, B., Waymire, J. C., Lees, G. J., Vernadakis, A., and Weiner, N., 1973, Basal level of neurotransmitter synthesizing enzymes and effect of cyclic AMP agents on the morphological differentiation of isolated neuroblastoma clones, Nature New Biol. 241: 117–119.PubMedGoogle Scholar
  101. Rall, T. W., 1972, Role of adenosine 3’,5’-monophosphate (cyclic AMP) in action of catecholamines, Pharmacol. Rev. 24: 399–409.Google Scholar
  102. Reis, D. J., Hess, P., and Azmitia, E. C., 1970, Changes in enzymes subserving catecholamine metabolism in morphine tolerance and withdrawal in rat, Brain Res. 20: 309–312.PubMedGoogle Scholar
  103. Reis, D. J., Moorhead, D. T., Rifkin, M., Joh, T. H., and Goldstein, M., 1971, Changes in adrenal enzymes synthesizing catecholamines in attack behavior evoked by hypothalamic stimulation in the cat, Nature 229: 229–230.Google Scholar
  104. Richelson, E., 1973, Stimulation of tyrosine hydroxylase activity in an adrenergic clone of mouse neuroblastoma, by dibutyryl cyclic AMP, Nature New Biol. 242: 175–177.PubMedGoogle Scholar
  105. Richter, D., 1970, Protein metabolism and functional activity, in: Protein Metabolism of the Nervous System ( A. Lajtha, ed.), pp. 241–258, Plenum Press, New York.Google Scholar
  106. Robison, G. A., Butcher, R. W., and Sutherland, E. W., 1968, Cyclic AMP, Ann. Rev. Biochem. 37: 149–174.PubMedGoogle Scholar
  107. Scott, B. S., 1971, Effect of potassium on neuron survival in cultures of dissociated human nervous tissue, Exp. Neurol. 30: 297–308.Google Scholar
  108. Scott, B. S., and Fisher, K. C., 1970, Potassium concentration and number of neurons in cultures of dissociated ganglia, Exp. Neurol. 27: 16–22.Google Scholar
  109. Sedvall, G. C., and Kopin, I. J., 1967, Influence of sympathetic denervation and nerve impulse activity on tyrosine hydroxylase in the rat submaxillary gland, Biochem. Pharmacol. 16: 39–46.Google Scholar
  110. Segal, D. S., Sallivan, J. L., Kuczenski, R. T., and Mandell, A. J., 1971, Effects of long-term reserpine treatment on brain tyrosine hydroxylase and behavioral activity, Science 173: 847–849.PubMedGoogle Scholar
  111. Segal, D. S., Knapp, S., Kuczenski, R. T., and Mandell, A. J., 1973, The effects of environmental isolation on behavior and regional rat brain tyrosine hydroxylase and tryptophan hydroxylase activities, J. Behav. Biol. 8: 47–53.Google Scholar
  112. Silberstein, S. D., Lemberger, L., Klein, D. C., Axelrod, J., and Kopin, I. J., 1972, Induction of adrenal tyrosine hydroxylase in organ culture, Neuropharmacology 11: 721–726.PubMedGoogle Scholar
  113. Singer, G., Ho, A., and Geshon, S., 1971, Changes in activity of choline acetylase in central nervous system of rat after intraventricular administration of noradrenaline, Nature 230: 152–153.Google Scholar
  114. Smith, A. D., DePotter, W. P., Moerman, E. J., and DeSchaepdryver, A. F., 1970, Release of dopamine β-hydroxylase and chromogranin A upon stimulation of the splenic nerves, Tissue Cell 2: 547–568.PubMedGoogle Scholar
  115. Snider, S. R., and Carlsson, A., 1972, The adrenal dopamine as an indicator of adrenomedul- lary hormone biosynthesis, Naunyn-Schmiedebergs Arch. Pharmacol. 275: 347–357.Google Scholar
  116. Thoenen, H., 1970, Induction of tyrosine hydroxylase in peripheral and central adrenergic neurons by cold exposure of rats, Nature 228: 861–862.PubMedGoogle Scholar
  117. Thoenen, H., 1972a, Neuronally mediated enzyme induction in adrenergic neurons and adrenal chromaffin cells, Biochem. Soc. Symp. 36: 3–15.Google Scholar
  118. Thoenen, H., 19726, Comparison between the effect of neuronal activity and nerve growth factor on enzymes involved in the synthesis of norepinephrine, Pharmacol. Rev. 24: 255–267.Google Scholar
  119. Thoenen, H., 1972c, Chemical sympathectomy: A new tool in the investigation of the physiology and pharmacology of peripheral and central adrenergic neurons, in: Perspectives in Neuropharmacology ( S. H. Snider, ed.), pp. 301–338, Oxford University Press, New York.Google Scholar
  120. Thoenen, H., and Oesch, F., 1973, New enzyme synthesis as a long-term adaptation to increased transmitter utilization, in: New Concepts in Neurotransmitter Regulation ( A. J. Mandell, ed.), pp. 33–51, Plenum, New York.Google Scholar
  121. Thoenen, H., and Tranzer, J. P., 1968, Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine, Naunyn-Schmiedebergs Arch. Phar-macol. 261: 271–288.Google Scholar
  122. Thoenen, H., Mueller, R. A., and Axelrod, J., 1969a, Increased tyrosine hydroxylase activity after drug-induced alteration of sympathetic transmission, Nature 221: 1264.PubMedGoogle Scholar
  123. Thoenen, H., Mueller, R. A., and Axelrod, J., 19696, Trans-synaptic induction of adrenal tyrosine hydroxylase, J. Pharmacol. Exp. Ther. 169: 249–254.Google Scholar
  124. Thoenen, H., Mueller, R. A., and Axelrod, J., 1970, Phase difference in the induction of tyrosine hydroxylase in cell body and nerve terminals of sympathetic neurones, Proc. Natl. Acad. Sci. 65: 58–62.PubMedGoogle Scholar
  125. Thoenen, H., Mueller, R. A., and Axelrod, J., 1970, Neuronally dependent induction of adrenal phenylethanolamine-N-methyltransferase by 6-hydroxydopamine, Biochem. Phar-macol. 19: 669–673.Google Scholar
  126. Thoenen, H., Kettler, R., Burkhard, W., and Saner, A., 1971, Neuronally mediated control of enzymes involved in the synthesis of norepinephrine: Are they regulated as an operational unit? Naunyn-Schmiedebergs Arch. Pharmacol. 270: 146–160.Google Scholar
  127. Thoenen, H., Saner, A., Angeletti, P. U., and Levi-Montalcini, R., 1972a, Increased activity of choline acetyltransferase in sympathetic ganglia after prolonged administration of nerve growth factor, Nature 236: 26–28.Google Scholar
  128. Thoenen, H., Kettler, R., and Saner, A., 19726, Time course of the development of enzymes involved in the synthesis of norepinephrine in the superior cervical ganglion of the rat from birth to adult life, Brain Res. 40: 459–468.Google Scholar
  129. Thoenen, H., Saner, A., Kettler, R., and Angeletti, P. U., 1972c, Nerve growth factor and preganglionic cholinergic nerves: Their relative importance to the development of the terminal adrenergic neuron, Brain Res. 44: 593–602.PubMedGoogle Scholar
  130. Tomkins, G. M., Levinson, B. B., Baxter, J. D., and Dettilefsen, L., 1972, Further evidence for posttranscriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells, Nature 239: 9–14.Google Scholar
  131. Udenfriend, S., and Dairman, W., 1971, Regulation of norepinephrine synthesis, Advan. Enzyme Regul. 9: 145–165.Google Scholar
  132. Viveros, O. H., Arqueros, L., and Kirschner, N., 1968, Release of catecholamines and dopamine β-hydroxylase from the adrenal medulla, Life Sci. 7: 609–618.Google Scholar
  133. Viveros, O. H., Arqueros, L., Connett, R. J., and Kirshner, N., 1969, Mechanism of secretion from the adrenal medulla. IV. The fate of storage vesicles following insulin and reserpine administration, Mol. Pharmacol. 5: 69–82.Google Scholar
  134. Waymire, J. C., Weiner, N., and Prasad, K. N., 1972, Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: Elevation induced by analogs of adenosine 3’,5’-cyclic monophosphate, Proc. Natl. Acad. Sci. 69: 2241–2245.PubMedGoogle Scholar
  135. Weiner, N., and Mosimann, W. F., 1970, The effect of insulin on catecholamine content and tyrosine hydroxylase activity of cat adrenal glands, Biochem. Pharmacol. 19: 1189–1199.Google Scholar
  136. Weiner, N., Cloutier, G., Bjur, R., and Pfeffer, R. I., 1972, Modification of norepinephrine synthesis in intact tissue by drugs and during short-term adrenergic nerve stimulation, Pharmacol. Rev. 24: 203–222.Google Scholar
  137. Weinshilboum, R. M., Thoa, N. B., Johnson, D. G., Kopin, I. J., and Axelrod, J., 1971, Proportional release of norepinephrine and dopamine β-hydroxylase from sympathetic nerves, Science 174: 1349–1351.PubMedGoogle Scholar
  138. Wurtman, R. J., and Axelrod, J., 1966, Control of enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids, J. Biol. Chem. 241: 2301–2305.PubMedGoogle Scholar
  139. Wurtman, R. J., Pohorecky, L. A., and Baliga, B. S., 1972, Adrenocortical control of the biosynthesis of epinephrine and proteins in the adrenal medulla, Pharmacol. Rev. 24: 411–426.Google Scholar
  140. Zivkovic, B., Guidotti, A., and Costa, E., 1973, Increase of tryptophan hydroxylase activity elicited by reserpine, Brain Res. 57: 522–526.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Hans Thoenen
    • 1
  1. 1.Department of PharmacologyBiocenter of the UniversityBaselSwitzerland

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