Advertisement

Brain Histamine

  • Kenneth M. Taylor
Part of the Handbook of Psychopharmacology book series (HBKPS, volume 3)

Abstract

Since the identification of histamine in brain tissue in 1943 (Kwiatowski, 1943), there has been controversy over what role this compound may play in the central nervous system. Thus histamine in the brain has been proposed to be involved in the etiology of schizophrenia (see review, Green, 1964), Parkinson’s disease (Unger and Witten, 1963), temperature regulation (Shaw, 1971), motion sickness (Crossland, 1971), and migraine (Sjaastad and Sjaastad, 1970). It has even been proposed as a biochemical mechanism for the efficacy of acupuncture (Popkin, 1972). This controversy is undoubtedly due to methodological problems in the study of histamine, whose simple chemical structure does not have any useful physical or chemical properties that can be utilized for assay. This led to the development of sensitive bioassay and fluorometric techniques for the assay of histamine. Whereas these techniques were invaluable for the study of histamine in peripheral organs, their application to brain tissue was limited owing to their lack of specificity.

Keywords

Biogenic Amine Histamine Level Diamine Oxidase Histidine Decarboxylase Histamine Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adam, H. M., 1961, Histamine in the central nervous system and hypophysis of the dog, in Regional Neurochemistry ( S. S. Kety and J. Elkes, eds.), pp. 293–306, Pergamon Press, London.Google Scholar
  2. Adam, H. M., 1967, as quoted by Green, J. P., 1970, Histamine, in Handbook of Neurochemistry, Vol. 4 ( A. Lathja, ed.), pp. 221–250, Plenum Press, New York.Google Scholar
  3. Adam, H. M., and Hye, H. K. A., 1966, Concentration of histamine in different parts of brain and hypophysis of cat and its modification by drugs, Brit. J. Pharmacol. 28: 137–152.Google Scholar
  4. Adam, H. M., Hye, H. K. A., and Watson, N. G., 1964, Studies on uptake and formation of histamine by hypophysis and hypothalamus in the cat, J. Physiol. 175: 70–7I P.Google Scholar
  5. Anton, A. H., and Sayre, D. F., 1969, A modified fluorometric procedure for tissue histamine and its distribution in various animals, J. Pharmacol. Exp. Ther. 166: 285–292.PubMedGoogle Scholar
  6. Atack, C., 1971, Reduction of histamine in mouse brain by N,(dl-seryl)-iV2-(2,3,4- trihydroxybenzyl) hydrazine and reserpine, J. Pharm. Pharmacol. 23: 992–993.PubMedGoogle Scholar
  7. Aures, D., Fleming, R., and Hakanson, R., 1968, Separation and detection of biogenic amines by thin-layer chromatography: Microanalysis of tissue amines and of enzymes involved in their metabolism, J. Chromatog. 33: 480–493.Google Scholar
  8. Axelrod, J., MacLean, P. D., Albers, R. W., and Weissbach, H., 1961, Regional distribution of methyltransferase enzymes in the nervous system and glandular tissues, in: Regional Neurochemistry ( S. S. Kety and J. Elkes, eds.), pp. 307–311, Pergamon Press, London.Google Scholar
  9. Axelsson, S., Bjorklund, A., Falck, B., Lindvall, O., and Svensson, L. A., 1973 Glyoxylic acid condensation; A new fluorescence method for the histochemical demonstration of biogenic amines, Acta Physiol. Scand. 87: 57–62.Google Scholar
  10. Baldessarini, R. J., and Kopin, I. J., 1967, The effect of drugs on the release of norepinephrine-H3 from central nervous system tissues by electrical stimulation in vivo, J. Pharmacol. Exp. Ther. 156: 31–38.PubMedGoogle Scholar
  11. Barnett, A., Taber, R. I., and Roth, F. E., 1969, Activity of antihistamines in laboratory antidepressant tests, Int. J. Neuropharmacol. 8: 73–79.PubMedGoogle Scholar
  12. Barnett, A., Malick, J. B., and Taber, R. I., 1971, Effects of antihistamines on isolation- induced fighting in mice, Psychopharmacologia 19: 359–365.PubMedGoogle Scholar
  13. Baudry, M., Matres, M.-P., and Schwartz, J. C., 1973a, The subcellular localization of histidine decarboxylase in various regions of the brain, J. Neurochem. 21: 1301–1309.PubMedGoogle Scholar
  14. Baudry, M., Chast, F., and Schwartz, J. C., 19736, Studies on S-adenylhomocysteine inhibition of histamine transmethylation in brain, J. Neurochem. 20: 13–21.Google Scholar
  15. Bauman, J. W., Phillips, F. S., and Ileiv, V., 1970, Thyroid hormone and brain histamine, Fed. Proc. 29: 835 (abst.).Google Scholar
  16. Bennett, C. T., Pert, A., Gall, K. J., and Blair, J. R., 1973, “Histaminergic” release of vasopressin: Functional role of histamine in the cat supraoptic nucleus, Fed. Proc. 32:221 (abst.).Google Scholar
  17. Bhargava, K. P., Kutshrestha, V. K., Santhakumari, E., and Srivastava, Y. P., 1973, Mechanism of histamine-induced antidiuretic response, Brit. J. Pharmacol. 47: 700–706.Google Scholar
  18. Bisset, G. W., Clark, B. J., and Errington, M. L., 1971, The hypothalamic neurosecretory pathways for the release of oxytocin and vasopressin in the cat, J. Physiol. 217: 111–131.PubMedGoogle Scholar
  19. Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R. and Parsons, E. M., 1972, Definition and antagonism of histamine-H2 receptors, Nature 236: 385–390.PubMedGoogle Scholar
  20. Boissier, J. R., Guernet, M.,Tillement, J. P., Blanco, I., and Blanco, M., 1970, Variations in brain histamine levels caused by diphenhydramine and l-histidine in the rat, Life Sci. 9 (l): 249–256.Google Scholar
  21. Brodie, B. B., Costa, E., Dlabac, A., Neff, N. H., and Smookler, H. H., 1966, Application of steady-state kinetics to the estimation of synthesis rates and turnover time of tissue catecholamines, J. Pharmacol. Exp. Ther. 154: 493–498.PubMedGoogle Scholar
  22. Brooks, C. J., and Horning, E. C., 1964, Gas chromatographic studies of catecholamines, tryptamines and other biogenic amines and related compounds, Anal. Chem. 36: 1540–1545.Google Scholar
  23. Brown, D. D., Tomchick, R., and Axelrod, J., 1959, The distribution and properties of a histamine methylating enzyme, J. Biol. Chem. 234: 2948–2950.PubMedGoogle Scholar
  24. Burger, M. M., Bombik, B. M., Breckenridge, B. McL., and Sheppard, J. R., 1972, Growth control and cyclic alterations of cyclic AMP in the cell cycle, Nature New Biol. 239: 161–163.PubMedGoogle Scholar
  25. Burkard, W. P., Gey, K. F., and Pletscher, A., 1963, Diamine oxidase in the brain of vertebrates, J. Neurochem. 10: 183–186.PubMedGoogle Scholar
  26. Button, J. C., 1953, Hope and Help in Parkinson’s Disease, Vantage Press, New York.Google Scholar
  27. Campos, H. A., and Jurupe, H., 1970, Evidence for a cholinergic mechanism inducing histamine increase in the rat brain in vivo, Experientia 26: 746–747.PubMedGoogle Scholar
  28. Carlini, E. A., and Green, J. P., 1963, The subcellular distribution of histamine, slow reacting substance and 5-hydroxytryptamine in the brain of the rat, Brit. J. Pharmacol. 20: 264–277.Google Scholar
  29. Cesare, L. C., Carlini, R. S., and Carlini, E. A., 1967, Influence of histamine on the catatonia induced in mice by tetrabenazine and reserpine, Arch. Int. Pharmacodyn. Ther. 169: 26–34.PubMedGoogle Scholar
  30. Chase, T. N., Katz, R. I., and Kopin, I. J., 1969, Release of 3H-serotonin from brain slices, J. Neurochem. 16: 607–61, 5.Google Scholar
  31. Chasin, M., Rivkin, I., Mamrak, F., Samaniego, S. G., and Hess, S. M., 1971, a- and -Adrenergic receptors as mediators of accumulation of cyclic adenosine 3’,5’- monophosphate in specific areas of guinea pig brain, J. Biol. Chem. 246: 3037–3041.Google Scholar
  32. Chasin, M., Mamrak, F., Samaniego, S. G., and Hess, S. M., 1973, Characteristics of the catecholamine and histamine receptor sites mediating accumulation of cyclic adenosine 3’-5’-monophosphate in guinea pig brain, J. Neurochem. 21: 1415 - 1427.PubMedGoogle Scholar
  33. Cohn, C. K., Ball, G. G., and Hirsch, J., 1973, Histamine: Effect on self-stimulation, Science 180: 757–758.PubMedGoogle Scholar
  34. Constentin, J., Andre, J. M., Schwartz, J. L., and Boulu, R., 1972, Histamine endogène et thermorégulation, Compt. Rend. Soc. Biol. Paris 166: 1366–1369.Google Scholar
  35. Coyle, J. T., and Axelrod, J., 1972, Tyrosine hydroxylase in rat brain developmental characteristics, J. Neurochem. 19: 1117–1123.PubMedGoogle Scholar
  36. Coyle, J. T., and Snyder, S. H., 1969, Antiparkinsonian drugs: Inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action, Science 166: 899–901.Google Scholar
  37. Cross, S. A. M., Ewen, S. W. B., and Rost, F. W. D., 1971, A study of the methods available for the cytochemical localization of histamine by fluorescence induced with o-phthalaldehyde or acetaldehyde, Histochem. J. 3: 471–476.PubMedGoogle Scholar
  38. Crossland, J., 1971, Modern views on pharmacology. IX. Histamine and 5-hydroxytryptamine, Practitioner 207: 382–388.PubMedGoogle Scholar
  39. Crossland, J., and Mitchell, J. F., 1956, The effect on the electrical activity of the cerebellum of a substance present in cerebellar extracts, J. Physiol. 132: 391–405.PubMedGoogle Scholar
  40. Crossland, J., Woodruff, G. N., and Woodruff, J. H., 1966, The histamine content of brain during bulbocapnine-induced catalepsy, Life Sei. 5: 193–197.Google Scholar
  41. Curtis, D. R., and Davis, R., 1962, Pharmacological studies upon neurons of the lateral geniculate nucleus of the cat, Brit. J. Pharmacol. 18: 217–246.Google Scholar
  42. Deguchi, T., and Barchas, J., 1971, Inhibition of transmethylations of biogenic amines by 5-adenylhomocysteine, J. Biol. Chem. 246: 3175–3181.PubMedGoogle Scholar
  43. de Robertis, E., Rodriguez de Lores Arnaiz, G., Alberici, M., Butcher, R. W., and Sutherland, E. W., 1967, Subcellular distribution of adenylcyclase and cyclic phosphor- diesterase in rat brain cortex, J. Biol. Chem. 242: 3487–3493.Google Scholar
  44. Dismukes, R. K., and Snyder, S. H., 1974, Histamine turnover in rat brain, Brain Res. 78: 467–481.PubMedGoogle Scholar
  45. Dobbing, J., 1968, The development of the blood-brain barrier, in: Progress in Brain Research, Vol. 29 ( A. Lathja and D. Ford, eds.), pp. 417–424, Elsevier, Amsterdam.Google Scholar
  46. Dross, K., and Kewitz, H., 1972, Concentration and origin of choline in the rat brain, Naunyn-Schmiedebergs Arch. Pharmakol. 274: 91–106.Google Scholar
  47. Ehinger, B., Hakanson, R., Owman, C., and Sporrong, B., 1968, Histochemical demonstra-tion of histamine in paraffin sections by a fluorescence method, Biochem. Pharmacol. 17: 1997–1998.Google Scholar
  48. Fischer, F. G., and Bonn, H., 1957, Uber die Bestimmung von Spermin, Spermidin, and anderen biogenen Aminen nach papierelektrophoretischer Abtrennung und ihre Mengenverhältnisse in tierischen Organen, Hoppe-Seylers Z. Physiol. Chem. 308: 108–119.Google Scholar
  49. Fram, D. H., and Green, J. P., 1968, Methylhistamine in guinea pig brain, J. Neurochem. 15: 597–602.PubMedGoogle Scholar
  50. Freedman, D. X., and Fenichel, G., 1958, Effects of midbrain lesions on experimental allergy, Arch. Neurol. Psychiat. 79: 164–169.Google Scholar
  51. Friedman, A. H., and Rodichok, L. D., 1972, Circadian patterns in spermidine and histamine levels of mouse whole brain myelencephalon and liver, Fed. Proc. 31: 351 (abst.).Google Scholar
  52. Friedman, A. H., and Walker, C. A., 1968, Circadian rhythms in rat midbrain and caudate nucleus biogenic amine levels, J. Physiol. 197: 77–85.PubMedGoogle Scholar
  53. Friedman, A. H., and Walker, C. A., 1969, rat brain amines, blood histamine and glucose levels in relationship to circadian changes in sleep induced by pentobarbital sodium, J. Physiol. 202: 133–146.Google Scholar
  54. Gabarg, M., Krishnamoorthy, M. S., Feger, J., and Schwartz, J. C., 1973, Effects of mesencephalic and hypothalamic lesions on histamine levels in rat brain, Brain Res. 50: 361–367.Google Scholar
  55. Gerald, M. C., and Maickel, R. P., 1972, Studies on the possible role of brain histamine in behaviour, Brit. J. Pharmacol. 44: 462–471.Google Scholar
  56. Ghadimi, H., Partington, M. W., and Hunter, A., 1961, A familial disturbance of histidine metabolism, New Engl. J. Med. 265: 221–224.Google Scholar
  57. Glowinski, J., and Iversen, L. L., 1966, Regional studies of catecholamines in the rat brain. I. Disposition of H3-norepinephrine, H3-dopamine and H3-dopa in various regions of the brain, J. Neurochem. 13: 655–669.PubMedGoogle Scholar
  58. Green, J. P., 1964, Histamine and the nervous system, Fed. Proc. 23: 1095–1102.Google Scholar
  59. Green, J. P., 1970, Histamine, in: Handbook of Neurochemistry, Vol. 4 ( A. Lathja, ed.), pp. 221–250, Plenum Press, New York.Google Scholar
  60. Haas, H. L., Anderson, E. G., and Hosli, L., 1973, Histamine and metabolites: Their effects and interactions with convulsants on brain stem neurones, Brain Res. 51: 269–278.PubMedGoogle Scholar
  61. Hakanson, R., Juhlin, L., Owman, C., and Sporrong, B., 1970, Histochemistry of histamine: Microspectrofluorometric characterization of the fluorophores induced by o-phthaldial- dehyde, J. Histochem. Cytochem. 18: 93–99.PubMedGoogle Scholar
  62. Hakanson, R., Ronnberg, A. L., and Sjolund, K., 1972, Fluorometric determination of histamine with OPT: Optimum reaction conditions and tests of identity, Anal. Biochem. 47: 356–370.Google Scholar
  63. Hanig, J. P., and Seifter, J., 1973, The effects of parenteral administration of catecholamines, serotonin and histamine on behaviour and levels of these amines in the brain of the neonate chick, Arch. Int. Pharmacodyn. Ther. 202: 38–47.PubMedGoogle Scholar
  64. Harris, G. W., Jacobsohn, D., and Kahlson, G., 1952, The occurrence of histamine in cerebral regions related to the hypophysis, in: Ciba Foundation Colloquia on Endocrinology, Vol. 4 ( G. E. W. Wolstenholme, ed.), pp. 186–196, Churchill Press, London.Google Scholar
  65. Haubrich, D. R., and Denzer, J. S., 1973, Simultaneous extraction and fluorometric measurement of brain serotonin, catecholamines, 5-hydroxyindoleacetic acid and homovanillic acid, Anal. Biochem. 55: 306–312.Google Scholar
  66. Heath, R. G., Leach, B. E., and Verster, F. D., 1962, in: Hallucinations, (L. J. West,ed.)Grune and Stratton, New York, p. 183.Google Scholar
  67. Heise, G. A., Laughlin, N., and Keller, C., 1970, a behavioural and pharmacological analysis of reinforcement withdrawal, Psychopharmacologia 16: 345–368.Google Scholar
  68. Horovitz, Z. P., Piala, J. J., High, J. P., Burke, J. C., and Leaf, R. C., 1966, Effects of drugs on the mouse killing (muricide) test and its relationship to amygdaloid function, Int. J. Neuropharmacol. 5: 405–411.PubMedGoogle Scholar
  69. Jaju, B. P., and Wang, S. C., 1971, Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: A search for the locus of their antimotion sickness action, J. Pharmacol. Exp. Ther. 176: 718–724.PubMedGoogle Scholar
  70. Jones, I. H., Stevenson, J., Jordan, A., Connell, H. M., Hetherington, H. D. G., and Gibney, G. N., 1973, Pheniramine as an hallucinogen, Med. J. Austral. 1: 382–386.Google Scholar
  71. Juhlin, L., and Shelley, W. B., 1966, Detection of histamine by a new fluorescent o-phthalal- dehyde stain, J. Histochem. Cytochem. 14: 525–528.PubMedGoogle Scholar
  72. Kahlson, G., and Rosengren, E., 1968, New approaches to the physiology of histamine, Physiol. Rev. 48: 155–196.Google Scholar
  73. Kahlson, G., Rosengren, E., Svahn, D., and Thunberg, R., 1964, Mobilization and formation of histamine in the gastric mucosa as related to acid secretion, J. Physiol. 174: 400–416.PubMedGoogle Scholar
  74. Kataoka, K., and de Robertis, E., 1967, Histamine in isolated small nerve endings and synaptic vesicles of rat brain cortex, J. Pharmacol. Exp. Ther. 156: 114–125.PubMedGoogle Scholar
  75. Kato, G., Tan, E., and Yung, J., 1972, Allosteric properties of acetylcholinesterase, Nature New Biol. 236: 185.PubMedGoogle Scholar
  76. Kelsall, M. A., and Lewis, P., 1964, Mast cells in the brain, Fed. Proc. 23: 1107–1108.Google Scholar
  77. Kobayashi, Y., and Maudsley, D. V., 1972, A single-isotope enzyme assay for histamine, Anal. Biochem. 46: 85–90.Google Scholar
  78. Kremzmer, L. T., and Pfeiffer, C. C., 1966, Identification of substances interfering with the fluorometric determination of brain histamine, Biochem. Pharmacol. 15: 197–200.Google Scholar
  79. Krishna, G., Forn, J., Voight, K., Paul, M., and Gessa, G. L., 1970, Dynamic aspects of neurohormonal control of cyclic 3’,5’-AMP synthesis in brain, Advan. Biochem. Psychopharm. 3: 155–172.Google Scholar
  80. Krnjevic, K., and Phillis, J. W., 1963, Actions of certain amines on cerebral cortical neurones, Brit. J. Pharmacol. 20: 471–490.Google Scholar
  81. Kuhar, M. J., Taylor, K. M., and Snyder, S. H., 1971, The subcellular localization of histamine and histamine methyltransferase in rat brain, J. Neurochem. 18: 1515–1527.PubMedGoogle Scholar
  82. Kwiatowski, H., 1943, Histamine in nervous tissue, J. Physiol. 102: 32–41.Google Scholar
  83. Lagunoff, D., 1972, The mechanism of histamine release from mast cells, Biochem. Pharmacol. 21: 1889–1896.Google Scholar
  84. Leonard, B. E., and Tonge, S. R., 1970, Some effects of an hallucinogenic drug (phencyclidine) on neurohumoral substances, Life Sci. 9 (1): 1141–1152.Google Scholar
  85. Levine, R. J., 1966, Histamine synthesis in man: inhibition by 4-bromo-3- hydroxybenzyloxyamine. Science: 154: 1017–1019.PubMedGoogle Scholar
  86. Levine, R. J., and Watts, D. E., 1966, a sensitive and specific assay for histidine decarboxylase activity, Biochem. Pharmacol. 15: 841–849.Google Scholar
  87. Levine, R. J., Sato, T. L., and Sjoerdsma, A., 1965, Inhibition of histamine synthesis in the rat by an a-hydrazino analog of histidine and 4-bromo-3-hydroxy benzyloxamine, Biochem. Pharmacol. 14: 139–149.Google Scholar
  88. Lewis, T., 1927, The Blood Vessels of the Human Skin and Their responses, Shaw, London.Google Scholar
  89. Lichtenstein, L. M., and Margolis, S., 1968, Histamine release in vitro: Inhibition by catecholamines and methylxanthines, Science 161: 902–903.PubMedGoogle Scholar
  90. Lindell, S. E., and Schayer, R. W., 1958, Metabolism of C14-histaminein the kidney of the dog, Brit. J. Pharmacol. 13: 52–53.Google Scholar
  91. Lipinski, J. F., Schaumberg, H. H., and Baldessani, R. J., 1973, Regional distribution of histamine in human brain, Brain Res. 52: 403–408.PubMedGoogle Scholar
  92. Marrazzi, A. S., Hart, E. R., and Gilfoil, T. M., 1961, A potential histaminogenic (allergic) mechanism for psychosis, Rec. Advan. Biol. Psychiat. 3: 164.Google Scholar
  93. Marx, J. L., 1972, Prostaglandins: Mediators of Inflammation, Science 177: 780–781.PubMedGoogle Scholar
  94. McIntire, F. C., 1966, Determination of histamine by chemical means, in: Handbook of Experimental Pharmacology (O. Eichler and A. Farah, Eds.), Part 1, pp. 57–80, Springer, New York.Google Scholar
  95. Medina, M., and Shore, P. A., 1966, Increased sensitivity in a specific fluorometric method for brain histamine, Biochem. Pharmacol. 15: 1627–1629.Google Scholar
  96. Medina, M. A., Butler, W., and Lincoln, G., 1972, Alteration of brain histamine in discrete areas, Fed. Proc. 31: 531 (abst.).Google Scholar
  97. Melmon, K. L., Bourne, H. R., Weinstein, J., and Sela, M., 1972, Receptors for histamine can be detected on the surface of selected leucocytes, Science 177: 707–709.PubMedGoogle Scholar
  98. Menon, M. K., Aures, D., and Clark, W. G., 1970, Lowering of brain histamine by parachlorophenylalanine and a new histidine decarboxylase inhibitor, Pharmacologist 12: 205.Google Scholar
  99. Menon, M. K., Clark, W. G., and Aures, D., 1971, Effect of thiazol-4-ylmethyoxyamine, a new inhibitor of histamine biosynthesis on brain histamine, monoamine levels and behaviour, LifeSci. 10 (1): 1097–1109.Google Scholar
  100. Michaelson, I. A., and Coffman, P. Z., 1967, The subcellular localization of histamine in guinea pig brain—a re-evaluation, Biochem. Pharmacol. 16: 2085–2090.Google Scholar
  101. Michaelson, I. A., and Coffman, P. Z., 1969, An improved ion-exchange purification procedure for the fluorometric assay of histamine, Anal. Biochem. 27: 257–261.Google Scholar
  102. Michaelson, I. A., Coffman, P. Z., and Vedral, D. F., 1968, The regional distribution of histamine in the brain of the rhesus monkey (Macaca mulatto), Biochem. Pharmacol. 17: 2435–2441.Google Scholar
  103. Milmore, J. E., and Hammerman, D. L., 1969, Chlorpromazine inhibition of dehydration- induced antidiuresis in rats, J. Pharmacol. Exp. Ther. 166: 63–67.PubMedGoogle Scholar
  104. Monnier, M., Fallert, M., and Bhattacharya, I., 1967, The waking action of histamine, Experientia 23: 21–25.PubMedGoogle Scholar
  105. Mrsulja, B. B., 1973, The influence of antistine on glycogenolytic effect of some biogenic amines in rat brain slices, Experientia 29: 76–77.PubMedGoogle Scholar
  106. Neame, K. D., 1964, Uptake of histidine, histamine and other imidazole derivatives by brain slices, J. Neurochem. 11: 655–662.PubMedGoogle Scholar
  107. Neff, N. H., Ngai, S. H., Wang, C. T., and Costa, E., 1969, Calculation of the rate of catecholamine synthesis from the rate of conversion of,4C-tyrosine to catecholamines: Effect of adrenal demedullation on synthesis rates, Mol. Pharmacol. 5: 90–99.Google Scholar
  108. Neff, N. H., and Tozer, T. N., 1968. In vivo measurement of brain serotonin turnover. Adv. Pharmacol. 6A: 97–109.PubMedGoogle Scholar
  109. Noda, H., and Adey, W. R., 1973, Neuronal activity in the association cortex of the cat during sleep, wakefulness and anesthesia, Brain Res. 54: 243–259.PubMedGoogle Scholar
  110. Oreland, L., 1972, Some properties of pig liver mitochondrial monoamine oxidase, in: Advances in Biochemical psychopharmacology, Vol. 5 ( E. Costa and P. Greengard, eds.), pp. 37–43, Raven Press, New York.Google Scholar
  111. Palmer, G. C., Schmidt, M. J., and Robison, G. A., 1972, Development and characteristics of the histamine induced accumulation of cyclic AMP in the rabbit cerebral cortex,]. Neurochem. 19: 2251–2256.Google Scholar
  112. Pearce, L. A., and Schanberg, S. M., 1969, Histamine and spermidine content in brain during development, Science 166: 1301–1303.PubMedGoogle Scholar
  113. Perry, T. L., Hansen, S., Foulks, J. G., and Ling, G. M., 1965, Aliphatic and aromatic amines of cat brain, J. Neurochem. 12: 397–405.PubMedGoogle Scholar
  114. Pert, C. B., and Snyder, S. H., 1973, Opiate receptor: Demonstration in nervous tissue, Science 179: 1011–1014.PubMedGoogle Scholar
  115. Pfeiffer, C. C., Iliev, V., and Goldstein, L., 1970, Blood histamine, polyamines and the schizophrenias: Computer correlations of the low and high blood histamine types, Res. Commun. Chem. Pathol. Pharmacol. 1: 247–265.PubMedGoogle Scholar
  116. Phillis, J. W., Tebecis, A. K., and York, D. H., 1968, Histamine and some antihistamines: Their actions on cerebral cortex neurones, Brit. J. Pharmacol. 33: 426–440.Google Scholar
  117. Pollard, H., Bischoff, S., and Schwartz, J. C., 1973, Decrease of histamine synthesis in the rat brain by hypnotics and sedatives, J. Pharm. Pharmacol. 25: 920–922.PubMedGoogle Scholar
  118. Pollin, W., Cardon, P. V., and Kety, S. S., 1961, Effects of amino acid feedings in schizophrenic patients treated with iproniazid, Science 133: 104–105.PubMedGoogle Scholar
  119. Popkin, R. J., 1972, Histamine explanation of acupuncture, J. Am. Med. Assoc. 220: 1359.Google Scholar
  120. Reichelt, K. L., and Kvamme, E., 1973, Histamine-dependent formation of N-acetyl-aspartyl peptides in mouse brain, J. Neurochem. 21: 849–859.PubMedGoogle Scholar
  121. Riley, J. F., 1959, The Mast Cells, Livingstone, Edinburgh.Google Scholar
  122. Roberts, E., and Simonsen, D. G., 1970, Some properties of cyclic 3’,5’-nucleotide phos-phodiesterase of mouse brain: Effects of imidazole-4-acetic acid, chlorpromazine, cyclic 3’,5’-GMP, and other substances, Brain Res. 24: 91–111.PubMedGoogle Scholar
  123. Robinson, J. D., Anderson, J. H., and Green, J. P., 1965, The uptake of 5-hydroxytryptamine and histamine by particulate fractions of brain, J. Pharmacol. Exp. Ther. 147: 236–243.PubMedGoogle Scholar
  124. Robison, G. A., Butcher, R. W., and Sutherland, E. W., 1971, Cyclic AMP, Academic Press, New York.Google Scholar
  125. Ronnberg, A. L., and Schwartz, J. C., 1969, Répartition régionale de l’histamine dans le cerveau de rat, Compt. Rend. Acad. Sci. Paris 268: 2376–2379.Google Scholar
  126. Rosenberg, F. J., and Savarie, P. J., 1964, Histamine and the reversal of chlorpromazine- induced depression, J. Pharmacol. Exp. Ther. 146: 180–185.PubMedGoogle Scholar
  127. Rost, F. W. D., and Ewan, S. W. B., 1971, New methods for the histochemical demonstration of catecholamines, tryptamines, histamine and other arylethylamines by acid- and aldehyde- induced fluorescence, Histochem. J. 3: 207–212.PubMedGoogle Scholar
  128. Schayer, R. W., 1956, The metabolism of histamine in various species, Brit. J. Pharmacol. 11: 472–473.Google Scholar
  129. Schayer, R. W., 1959, Catabolism of physiological quantities of histamine in vivo, Physiol. Rev. 39: 116–126.Google Scholar
  130. Schayer, R. W., 1960, Relationship of stress-induced histidine decarboxylase to circulatory homeostasis and shock, Science 131: 226–227.PubMedGoogle Scholar
  131. Schayer, R. W., 1968, Determination of histidine decarboxylase activity, in: Methods of Biochemical Analysis, Vol. 16 ( D. Glick, ed.), pp. 273–391, Interscience, New York.Google Scholar
  132. Schayer, R. W., and Reilly, M., 1973, Metabolism of,4C-histamine in brain, J. Pharmacol. Exp. Ther. 187: 34–39.PubMedGoogle Scholar
  133. Schmidt, D. E., Speth, R. C., Welsch, F., and Schmidt, M. J., 1972, The use of microwave radiation in the determination of acetylcholine in the rat brain, Brain Res. 38: 377–389.PubMedGoogle Scholar
  134. Schuberth, J., Sparf, B., and Sundwall, A., 1969, A technique for the study of acetylcholine turnover in mouse brain in vivo, J. Neurochem. 16: 695–700.PubMedGoogle Scholar
  135. Schwartz, J. C., Lampart, C., and Rose, C., 1970, Properties and regional distribution of histidine decarboxylase in rat brain, J. Neurochem. 17: 1527–1534.PubMedGoogle Scholar
  136. Schwartz, J. C., Pollard, H., Bischoff, S., and Verdiere-Sahuque, M., 1971a, Catabolism of 3H-histamine in the rat brain after intracisternal administration, Europ. J. Pharmacol. 16: 326–335.Google Scholar
  137. Schwartz, J. C., Lampart, C., Rose, C., Bischoff, S., Rehault, M. C., and Pollard, H., 19716, Histamine formation in rat brain during development, J. Neurochem. 18: 1787–1789.Google Scholar
  138. Schwartz, J. C., Lampart, C., and Rose, C., 1972, Histamine formation in rat brain in vivo: Effects of histidine loads, J. Neurochem. 19: 801–810.PubMedGoogle Scholar
  139. Schwartz, J. C., Rose, C., and Caillens, H., 1973, Metabolism of methylhistamine formed through a new pathway: Decarboxylation of l-3-methylhistidine, J. Pharmacol. Exp. Ther. 184: 766–779.PubMedGoogle Scholar
  140. Shank, R. P., and Aprison, M. H., 1970, The metabolism in vivo of glycine and serine in eight areas of the rat central nervous system, J. Neurochem. 17: 1461–1475.PubMedGoogle Scholar
  141. Shapiro, D. L., 1973, Morphological and biochemical alterations in foetal rat brain cells cultured in the presence of monobutyryl cyclic AMP, Nature 241: 203–204.PubMedGoogle Scholar
  142. Shaw, G. G., 1971, Hypothermia produced in mice by histamine acting on the central nervous system, Brit. J. Pharmacol. 42: 205–214.Google Scholar
  143. Shimizu, H., Creveling, C. R., and Daly, J. W., 1970, The effect of histamine and other compounds on the formation of adenosine 3’,5’-monophosphate in slices from cerebral cortex, J. Neurochem. 17: 441–444.PubMedGoogle Scholar
  144. Shore, P. A., Burkhalter, A., and Cohn, V. H., 1959, A method for the fluorimetric assay of histamine in tissues, J. Pharmacol. Exp. Ther. 127: 182–186.PubMedGoogle Scholar
  145. Sjaastad, O., and Sjaastad, O. V., 1970, The histaminuria in vascular headache, Acta Neurol. Scand. 46: 331–342.Google Scholar
  146. Snyder, S. H., and Axelrod, J., 1965, Sex differences and hormonal control of histamine methyltransferase activity, Biochim. Biophys. Acta 111: 416–421.Google Scholar
  147. Snyder, S. H., and Taylor, K. M., 1972, Histamine in the brain—A neurotransmitter? in: Perspectives in Neuropharmacology—A Tribute to Julius Axelrod ( S. H. Snyder, ed.), pp. 43–73, Oxford University Press, New York.Google Scholar
  148. Snyder, S. H., Baldessarini, R. J., and Axelrod, J., 1966a, A sensitive and specific enzymatic isotopic assay for tissue histamine, J. Pharmacol. Exp. Ther. 153: 544–549.PubMedGoogle Scholar
  149. Snyder, S. H., Glowinski, J., and Axelrod, J., 19666. The physiologic disposition of H3-histamine in the rat brain, J. Pharmacol. Exp. Ther. 153: 8–14.Google Scholar
  150. Snyder, S. H., Kreuz, D. S., Medina, V. J. and Russell, P. H., 1970, Polyamine synthesis and turnover in rapidly growing tissues, Ann. N.Y. Acad. Sci. 171: 749–771.Google Scholar
  151. Snyder, S. H., Brown, B., and Kuhar, M., 1974, The subsynaptosomal localization of histamine, histidine decarboxylase, the histamine methyltransferase in rat hypothalamus, J. Neurochem. 23: 37–45.PubMedGoogle Scholar
  152. Stein, L., 1962, New methods for evaluating stimulants and antidepressants, in: Psychosomatic Medicine ( J. H. Nodine and J. H. Moyers, eds.), pp. 297–311, Lea and Febiger, Philadelphia.Google Scholar
  153. Stone, T. W., 1971, Are noradrenaline excitations artifacts? Nature 234: 145–146.PubMedGoogle Scholar
  154. Tabor, H., and Tabor, C. W., 1964, Spermidine, spermine and related amines, Pharmacol. Rev. 16: 245–300.Google Scholar
  155. Taylor, K. M., 1973, Comparison of the antihistamine effect of burimamide and mepyramine and their effect on the activity of histamine methyltransferase, Biochem. Pharmacol. 22: 2775–2777.Google Scholar
  156. Taylor, K. M., and Laverty, R., 1973, The interaction of chlordiazepoxide, diazepam and nitrazepam with catecholamines and histamine in regions of the rat brain, in: The Benzodiazepines ( S. Garattini, E. Mussini, and L. O. Randall, eds.), pp. 191–202, Raven Press, New York.Google Scholar
  157. Taylor, K. M., and Snyder, S. H., 1971a, Histamine in rat brain: Sensitive assay of endogenous levels, formation in vivo and lowering by inhibitors of histidine decarboxylase, J. Pharmacol. Exp. Ther. 179: 619–633.PubMedGoogle Scholar
  158. Taylor, K. M., and Snyder, S. H., 19716, Brain histamine: Rapid apparent turnover altered by restraint and cold stress, Science, 173: 247–248.Google Scholar
  159. Taylor, K. M., and Snyder, S. H., 1972a, Isotopic microassay of histamine, histidine, histidine decarboxylase and histamine methyltransferase in brain tissue, J. Neurochem. 19: 1343–1358.PubMedGoogle Scholar
  160. Taylor, K. M., and Snyder, S. H., 19726, Dynamics of the regulation of histamine levels in mouse brain, J. Neurochem. 19: 341–354.Google Scholar
  161. Taylor, K. M., and Snyder, S. H., 1972c, Histamine methyltransferase: Inhibition and potentiation by antihistamines, Mol. Pharmacol. 8: 300–312.Google Scholar
  162. Taylor, K. M., and Snyder, S. H., 1973, The release of histamine from tissue slices of rat hypothalamus, J. Neurochem. 21: 1215–1223.PubMedGoogle Scholar
  163. Taylor, K. M., Gfeller, E. D., and Snyder, S. H., 1972a, Regional localization of histamine and histidine in the brain of the rhesus monkey, Brain Res. 41: 171–180.PubMedGoogle Scholar
  164. Taylor, K. M., Clark, D. W., Laverty, R„ and Phelan, E. L., 19726, Destruction of noradrenergic neurones in specific brain regions due to peripheral injection of 6-hydroxydopamine to newborn rats, Nature New Biol. 239: 247–248.Google Scholar
  165. Tham, R., 1966, Gas chromatography of ring-iV-methylated imidazoleacetic acids in human urine, Scand. J. Lab. Clin. Invest. 18: 603–616.Google Scholar
  166. Udenfriend, S., Stein, S., Bohler, P., Dairman, W., Leingruber, W., and Weigele, M., 1972, Fluorescamine: A reagent for assay of amino acids, peptides, proteins and primary amines in the picomole range, Science 178: 871–872.PubMedGoogle Scholar
  167. Unger, G., and Witten, J. W., 1963, Increase in brain histamine caused by tremorine, Fed. Proc. 22: 273 (abst.).Google Scholar
  168. van Balgooy, J. N., and Roberts, E., 1973, Methods for study of imidazole pounds and application to brain and cancer cells, Biochem. Pharmacol. 22: 1405–1415.Google Scholar
  169. van Balgooy, J. N. A., Marshall, F. D., and Roberts, E., 1972, Metabolism of intracerebrally administered histidine, histamine, and imidazoleacetic acid in mice and frogs, J. Neurochem. 19: 2341–2353.PubMedGoogle Scholar
  170. van Orden, L. S., 1970, Quantitative histochemistry of biogenic amines: A simple microspec- trofluorometer, Biochem. Pharmacol. 19: 1105–1117.Google Scholar
  171. Vugman, I., and Roche-Silva, M., 1966, Biological determination of histamine in living tissues and body fluids, in: Handbook of Experimental Pharmacology, Vol. 18 (O. Eichler and A. Farah, Eds.), Part 1, pp. 81–115, Springer, New York.Google Scholar
  172. White, T., 1961, Some effects of histamine and two histamine metabolites on the cats brain, J. Physiol. 159: 198–202.PubMedGoogle Scholar
  173. White, T., 1964, Biosynthesis, metabolism and function of histamine in the nervous system, Fed. Proc. 23: 1103–1108.Google Scholar
  174. White, T., 1965, Peripheral vascular effects of histamine administered into the cerebral ventricles of anaesthetized cats, Experientia 21: 132–133.PubMedGoogle Scholar
  175. White, T., 1966, Histamine and methylhistamine in cat brain and other tissues, Brit. J. Pharmacol. 26: 494–501.Google Scholar
  176. Wooten, G. F., Thoa, N. B., Kopin, I. J., and Axelrod, J., 1973, Enhanced release of dopamine β-hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic 3’,5’-monophosphate and theophylline, Mol. Pharmacol. 9: 178–183.Google Scholar
  177. Wurtman, R. J., Rose, C. M., Matthysse, S., Stephenson, J., and Baldessarini, R., 1970, l-Dihydroxyphenylalanine: Effect on S-adenosylmethionine in brain, Science 169: 395–397.Google Scholar
  178. Wyngaarden, J. B., and Seevers, M. H., 1951, The toxic effects of antihistaminic drugs, J. Am. Med. Assoc. 145: 277–282.PubMedGoogle Scholar
  179. Young, A. B., Pert, C. D., Brown, D. G., Taylor, K. M., and Snyder, S. H., 1971, Nuclear localization of histamine in neonatal rat brain, Science 173: 247–249.PubMedGoogle Scholar
  180. Zeller, E. A., 1972, Diamine oxidase: Specificity and mechanism, in: Advances in Biochemical Psychopharmacology, Vol. 5 ( E. Costa and P. Greengard, eds.), pp. 167–180, Raven Press, New York.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Kenneth M. Taylor
    • 1
  1. 1.The Squibb Institute for Medical ResearchPrincetonUSA

Personalised recommendations