New 5-Nitroimidazoles with Antiprotozoal Activity: Effect of Hoe 088 (Pirinidazole)
Preparation Hoe 088, a 1-Methyl-2-(pyridyl-2-thio-methyl)-5-nitro-imidazole, was found to be the compound from a series of new 5-nitro-imidazoles with the broadest action against protozoans. Its effect against trichomonads is the most pronounced. The comparison of the effective doses of different 5-nitroimidazoles against Trichomonas fetus demonstrates that the compound (Hoe 088) is slightly superior to Tinidazole, distinctly superior to Metronidazole, and very much superior to Nitrimidazine. As a supplementary basic model the subcutaneous abscess in the mouse caused by Trichomonas vaginalis was used for further assessing the trichomonacidal effect. None of the compounds tested could prevent the formation of abscesses in all animals at the dose of 4 times 100 mg/kg. After administration of Hoe 088 the smallest number of abscesses was counted. The next in order were the Tinidazol- and finally the Metronidazoletreated animals.
KeywordsEffective Dose Single Oral Dose Liver Abscess Acid Amide Golden Hamster
Unable to display preview. Download preview PDF.