A New Combination of Trimethoprim and a Sulphonamide (Sulphadiazine) in Urinary Tract Infections, a Double-Blind Study
The common problem of urinary tract infections (UTI) make every attempt to improve current therapy worthwhile. Trime thoprim-sulphamethoxazole (co-trimoxazole) and sulphalene have been shown to be useful drugs in the treatment of UTI. In order to decrease the dosages of trimethoprim as well as sulphonamide, sulphadiazine was chosen in the combination with trimethoprim with the purpose of diminishing possible side reactions without losing the clinical efficacy. This was regarded as possible as the concentration of unmetabolized sulphadiazine in the urine is much higher than that of sulphamethoxazole after medication of equal doses of the drugs. It should be emphasized that A 2166 was composed for the use in UTI exclusively. Thus a controlled study was started comparing the combination trimethoprim-sulphadiazine with co-trimoxazole and with sulphalene, a long-acting sulphonamide.
KeywordsSerum Creatinine Urinary Tract Infection Urine Level Tubular Secretion Equal Dose
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