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A New Combination of Trimethoprim and a Sulphonamide (Sulphadiazine) in Urinary Tract Infections, a Double-Blind Study

  • A. Lövestad
  • B. Gästrin
  • R. Lundström
Part of the Chemotherapy book series (CT, volume 6)

Abstract

The common problem of urinary tract infections (UTI) make every attempt to improve current therapy worthwhile. Trime thoprim-sulphamethoxazole (co-trimoxazole) and sulphalene have been shown to be useful drugs in the treatment of UTI. In order to decrease the dosages of trimethoprim as well as sulphonamide, sulphadiazine was chosen in the combination with trimethoprim with the purpose of diminishing possible side reactions without losing the clinical efficacy. This was regarded as possible as the concentration of unmetabolized sulphadiazine in the urine is much higher than that of sulphamethoxazole after medication of equal doses of the drugs. It should be emphasized that A 2166 was composed for the use in UTI exclusively. Thus a controlled study was started comparing the combination trimethoprim-sulphadiazine with co-trimoxazole and with sulphalene, a long-acting sulphonamide.

Keywords

Serum Creatinine Urinary Tract Infection Urine Level Tubular Secretion Equal Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. (1).
    Lövestad, A., Sabel, G., Stefansson, M., Gastrin, B., and Lundström, R., Trimethoprim — sulphamethaxole and nitrofurantoin in urinary tract infections, a controlled clinical study. Progress in Chemotherapy, proceedings 8th International Congress of Chemotherapy 1973. Vol n, p.234. Hellenic Soc. Chemotherapy, Athens 1974.Google Scholar
  2. (2).
    Pompeius, R., et al: J. Urol, (to be published).Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • A. Lövestad
    • 1
  • B. Gästrin
    • 1
  • R. Lundström
    • 1
  1. 1.Departments of Infectious Diseases and of Clinical BacteriologyCentral HospitalEskilstunaSweden

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