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Long-Term Low-Dosage CO-Trimoxazole in the Management of Urinary Tract Infection in Children

  • J. M. Smellie
  • R. N. Grüneberg
  • A. Leakey
  • W. S. Atkin
Part of the Chemotherapy book series (CT, volume 6)

Abstract

Long-term low-dosage prophylaxis is used in childhood urinary tract infection to prevent recurrence after the initial infection has been eradicated. Its use is indicated (1) in children whose kidneys are liable to damage from repeated infections, that is, those with vesico-ureteric reflux and chronic pyelonephritis (children with obstruction of the lower urinary tract having been identified and treated surgically) and (2) in children even with normal urinary tracts who are troubled by repeated symptomatic infections. (Normand & Smellie, 1965). For this purpose a drug is required which is effective, well tolerated, free from side effects and does not induce drug resistance. We have shown nitrofurantoin to be an efficient prophylactic drug (Gruneberg et al, 1973) but as it occasionally causes nausea we have also studied co-trimoxazole.

Keywords

Rectal Swab Urinary Tract Obstruction Bladder Defence Chronic Pyelonephritis Renal Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Forbes, P.A. & Drummond K.N. (1973). J.Inf.Dis. 128, S626.CrossRefGoogle Scholar
  2. Grüneberg, R.N., Smellie, J.M. & Leakey, A. (1973). In Urinary Tract Infection. Proc.2nd Nat.Sympos. p.131, ed. Brumfitt, W. and Asscher, W.A. Oxford Univ. Press.Google Scholar
  3. Normand, I.C.S. & Smellie, J.M. (1965). Brit.Med.J. 1, 1023.PubMedCrossRefGoogle Scholar
  4. Zoethout, H.E. (1973). In Trimethoprim/sulphamethox azole in bacterial infections, p.175. Ed. Bernstein, L.S. & Salter, A.J., Churchill Livingstone, Edinburgh.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • J. M. Smellie
    • 1
  • R. N. Grüneberg
    • 1
  • A. Leakey
    • 1
  • W. S. Atkin
    • 1
  1. 1.University College HospitalLondonEngland

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