The Concentration of Sulphamethoxazole and Trimethoprim in Human Prostate Gland
Sulphamethoxazole and trimethoprim concentrations were measured in 19 enucleated human prostate glands. For sulphamethoxazole the ratio plasma concentration to that of the prostate varied from 1.25 to 3.29. The trimethoprim concentrations were 2 to 3 times higher than in the plasma. These results are compared with the data of the literature. It seems obvious that the association SMZ-TMP is very useful in the treatment of chronic bacterial prostatitis.
KeywordsProstate Gland Nalidixic Acid Chronic Prostatitis Benign Prostate Hypertrophy Chronic Bacterial Prostatitis
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- Böhni E. (1969) Chemother, suppl. ad Vol.14, 1–21.Google Scholar
- Drach G.W. (1974) J. Urol. III, 637–639.Google Scholar
- Granato J.J., Gross D.M. and Stamey T.A. (1973) Invest. Urol. II, 205–210.Google Scholar
- Hirdes W.H. and Schönfeld J.K. (1973) Trimethoprim — Sulphamethoxazole in bacterial infections. Eds. L. Bernstein and A. Salter. London, Churchill Livingstone p.113Google Scholar
- Rieder J.(1972) unpublished data.Google Scholar
- Schirren C. und Schaller D. (1971) Androl. 3, 24.Google Scholar
- Schwartz D.E., Koechlin B.A. and Wenifeld R.E. (1969) Chemother, suppl. ad vol.14, 22–29.Google Scholar
- Schwartz D.E. (1972) unpublished data.Google Scholar
- Stamey T.A.(1972) Urinary infections. Baltimore, Williams and Wilkins Co. p. 199.Google Scholar
- Winningham D.G. and Stamey T.A. (1973) J. Urol. 104, 559–563.Google Scholar