Treatment of Human Brucellosis with Doxycycline and Trimethoprim — Sulfonamide
19 patients with different forms of brucellosis of bovine origin were treated with doxycycline (Vibramycin) 200 mg daily combined with trimethoprim — sulfonamide. Treatment was carried out for three weeks and was repeated when necessary. In subacute and chronic cases ACTH or prednisolone was also given and if a delayed type allergy was demonstrated a desensibilisation with specific antigen was also applied. No relapse or getting chronic had been noted in four acute cases with these doses, and two patients had relapsed with 100 mg doxycycline daily, after a good initial response. All five cases of subacute relapsing brucellosis had a complete recovery. No improvement had been achieved using antibiotics only in a case of chronic brucellosis and transitory regression of the symptomes in further severe cases can be attributed to additional therapy.
KeywordsAcute Case Human Brucellosis Veterinary Surgeon High Tissue Concentration Bovine Origin
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