Trimethoprim Resistance of Pathogenic Organisms Previous to Common Clinical use Op Sulprim(R)
About 1000 organisms (Esch. coli, Klebsiella, Pseudomonas, Enteritis-Coli, Proteus sp., Staph. aureus, Enterococci, Listeria monocytogenes) isolated from different materials of inpatients in 1973 and 1974 before Co-Trimoxazole was available were tested against TMP, SMZ and TMP/SMZ in the disk-diffusion test. We found that the percentage of resistant strains against the TMP/SMZ-combination for Esch.coli was only 1.3%, in. Klebsiella 4.8% and Enterococci 2%. As yet no resistant strain of Ent. coli, Proteus, Staph, aureus and Listeria monocytogenes against TMP/SMZ was stated. The favourable potentiating effect could also be demonstrated with the agar dilution method and the FIC-values. The resistant strains had only MIC-values to TMP between 3.12 and 50 ug/ml; TMP resistance (50 ug/ml) of 6 Klebsiella strains could not be transferred to Esch.coli K 12.
KeywordsResistant Strain Listeria Monocytogenes Klebsiella Pneumoniae Pathogenic Organism Proteus Mirabilis
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