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Trimethoprim Resistance of Pathogenic Organisms Previous to Common Clinical use Op Sulprim(R)

  • S. Ortel
Part of the Chemotherapy book series (CT, volume 6)

Summary

About 1000 organisms (Esch. coli, Klebsiella, Pseudomonas, Enteritis-Coli, Proteus sp., Staph. aureus, Enterococci, Listeria monocytogenes) isolated from different materials of inpatients in 1973 and 1974 before Co-Trimoxazole was available were tested against TMP, SMZ and TMP/SMZ in the disk-diffusion test. We found that the percentage of resistant strains against the TMP/SMZ-combination for Esch.coli was only 1.3%, in. Klebsiella 4.8% and Enterococci 2%. As yet no resistant strain of Ent. coli, Proteus, Staph, aureus and Listeria monocytogenes against TMP/SMZ was stated. The favourable potentiating effect could also be demonstrated with the agar dilution method and the FIC-values. The resistant strains had only MIC-values to TMP between 3.12 and 50 ug/ml; TMP resistance (50 ug/ml) of 6 Klebsiella strains could not be transferred to Esch.coli K 12.

Keywords

Resistant Strain Listeria Monocytogenes Klebsiella Pneumoniae Pathogenic Organism Proteus Mirabilis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • S. Ortel
    • 1
  1. 1.Inst, of Med. Microbiology and EpidemiologyHalle (SaaleGermany

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