Comparative Drug Trial in Cholera

  • A. F. B. Mabadeje
Part of the Chemotherapy book series (CT, volume 6)


During the cholera epidemic which broke out in Nigeria at the end of December 1970, it was observed during in vitro sensitivitytests that the isolated species of Vibrio cholerae was sensitive to “Septrin” the Wellcome brand of co-trimoxazole. Tetracycline was the recommended drug of first choice. Permission was then sought from the Professor of Medicine to carry out a comparative trail of drugs in patients admitted to the Cholera Ward of the Lagos University Teaching Hospital. The trial began in January 1971 and it was prematurely terminated in April 1971.


Magnesium Sulphate Rectal Swab Entamoeba Histolytica Slide Agglutination Test Negative Stool 


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  1. 1.
    Barua, D. and Cvjetanovic, B. 1970: The Surveillance of Cholera. W.H.O. Chronicle 24, 41–46.Google Scholar
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    Oni, O.O.A. 1971: Cholera Epidemic in Ihadan, January to March 1971. Nig. Med. J. I. 229–233.Google Scholar
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    Salami, M.Y.L. 1972: Clinical and Epidemiological Aspects of Cholera Outbreak in Metropolitan Lagos. Nig. Med. J.2. 149.155.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • A. F. B. Mabadeje
    • 1
  1. 1.Departments of Pharmacology and Medicine, College of MedicineUniversity of LagosLagosNigeria

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