Anti-Herpes Simplex Virus (HSV) Effect of Amphotericin B Methyl Ester in Vivo
Amphotericin B methyl ester (AME), semisynthetic derivative of amphotericin B, was studied for its anti-herpes simplex virus (HSV) effect in the rabbit cornea. It was highly active in preventing HSV-lesions, and its antiviral effect was linearly related to the logarithmic dose of AME. The antiviral activity was at least additive with that of 5-iodo-2’-deoxyuridine (IDU). It is suggested that AME should be active against IDU-resistant HSV and herpetic kerato-uveitis. Possibilities of use of AME against other viral diseases are discussed.
KeywordsAntiviral Effect Rabbit Cornea Infectivity Titre Semisynthetic Derivative Corneal Infectivity
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