“In Vivo” Depression of Either Endotoxin or Virus-Induced Interferons by Rifampicin and Rifamycin Derivatives

  • E. Ronda
  • M. L. Alonso
  • I. Barasoain
Part of the Chemotherapy book series (CT, volume 6)


Several experiments have been carried out in relation to the influence of rifamycin molecules on the interferon production when NDV and two bacterial lipopolysaccharides were employed as inducers. The highest interferon level was obtained by NDV and all the maximal peaks of yield appeared between 4 – 6 hr intervals. Antibiotics clearly blocked the interferon depending on an appropiate timing of drug and inducer. The most effective time was the injection of drug 4 hrs before the inducer had been administered.


Newcastle Disease Virus Vesicular Stomatitis Virus Bacterial Lipopolysaccharide Interferon Production Interferon Inducer 
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  1. Barasoain, I., Rubio, N., Espinosa, M. and Portolés, A. (1975) z. Bakt. Infek. Paras. (in press).Google Scholar
  2. Dajani, B.M., Kasik, J.E. and Thompson, J.S. (1973) Antimicrobial Ag. Chemotherap. 3, 451CrossRefGoogle Scholar
  3. Floersheim, G.L. (1973) Experientia 29, 1545PubMedCrossRefGoogle Scholar
  4. Gadaleta, M.N., Greco, M. and Saccone, C. (1970) FEBS Letters, 10, 54PubMedCrossRefGoogle Scholar
  5. Juhasz, P.P., Benecke, B.J. and Seifart, K.H. (1972) FEBS Letters 27, 30PubMedCrossRefGoogle Scholar
  6. Leorig, D., Diaz, R., Milner, K., Rudbach, J. and Wilson, J.B. (1970) Infec. Immun. 1, 174Google Scholar
  7. Maggi, N., Pallanza, R. and Sensi, P. (1966) Antimicrob. Ag Chemotherap. p. 765Google Scholar
  8. Merigan, T.C. (1973) In N.B. Finter ed. “Interferons and interferon inducers”. Chapter 4, p. 45 North-Holland. Amsterdam, London.Google Scholar
  9. Paunescu, E. (1970) Nature 228, 1188PubMedCrossRefGoogle Scholar
  10. Ronda, E. and Alonso, M.L. (1973) Abst. IV National Congr. of Microbiol. C5 0 Granada. SpainGoogle Scholar
  11. Ronda, E. and Alonso, M.L. (1974) Progress in Chemother (Athens) II, 1005Google Scholar
  12. Srb, V., Puza, V., Spurna, V. and Keprtova, J. (1974) Experientia 30, 484PubMedCrossRefGoogle Scholar
  13. Sung, S. Ch. (1974) Life Sciences 15, 359PubMedCrossRefGoogle Scholar
  14. Wehrli, W., Nuesch, J.; Knusel, F., Staehelin, M. (1968) Biochim. Biophys. Acta 157, 215PubMedCrossRefGoogle Scholar
  15. Westphal, O. and Jann, K. (1965) Methods in Carbohidrate chemistry, 5, 83Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • E. Ronda
    • 1
  • M. L. Alonso
    • 1
  • I. Barasoain
    • 1
  1. 1.Inst. “Jaime Ferrán” of Microbiology. C.S.I.C.Joaquin Costa32 - Madrid - Spain

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