“In Vivo” Depression of Either Endotoxin or Virus-Induced Interferons by Rifampicin and Rifamycin Derivatives
Several experiments have been carried out in relation to the influence of rifamycin molecules on the interferon production when NDV and two bacterial lipopolysaccharides were employed as inducers. The highest interferon level was obtained by NDV and all the maximal peaks of yield appeared between 4 – 6 hr intervals. Antibiotics clearly blocked the interferon depending on an appropiate timing of drug and inducer. The most effective time was the injection of drug 4 hrs before the inducer had been administered.
KeywordsNewcastle Disease Virus Vesicular Stomatitis Virus Bacterial Lipopolysaccharide Interferon Production Interferon Inducer
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