Effects of Pyrimidine Derivatives on RNA Dependent RNA Polymerase of Mengovirus Infected FL Cells

  • E. M. Tonew
  • B. Fahlbusch
Part of the Chemotherapy book series (CT, volume 6)


Virus: Mengovirus strain, plaque purified as previously described be TONEW and TONEW (1971).


Incorporation Rate Pyrimidine Derivative Pyrimidine Nucleoside Standard Reaction Mixture Viral ssRNA 
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  1. 1.
    Scherrer, K.B. and Darnell, J.E. (1972). Sedimentation characteristics of rapedly labeled RNA from He-La cells. Biochem. Biophys. Res. Commun. 7, 486–490.CrossRefGoogle Scholar
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    Tonev, M. and Tonew, E. (1971). Antivirale Wirkung von Imidazol Derivation I. Die Hemmung der Vermehrung des Mengovirus in FL Zellen. Arch ges. Virusforsch. 33, 319–329.CrossRefGoogle Scholar
  3. 3.
    Tonew, E., Loeber, G., and Tonew, M. (1974). The influence of antiviral isatinisothiosemicarbazones on RNA dependent RNA polymerase in Mengovirus-infected FL cells. Acta Virol, 18, 185–192.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • E. M. Tonew
    • 1
  • B. Fahlbusch
    • 1
  1. 1.Academy of Sciences of German Democratic Republic, Research Centre for Molecular Biology and Medicine, Central Institute for Microbiology and Experimental TherapyJenaGDR

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