In Vivo Topical Activity of the Interferon Inducer BRL 5907 and Ribavirin in Ferrets Infected with Influenza Virus
Many workers have shown that influenza infection in ferrets provides a highly relevant model for the infection in man (1) (2). The virus is readily transmitted from infected to non-infected animals and the progress of the disease can be monitored by body temperature, virus isolation and antibody assay. In this paper, we present data to show that the course of experimental infection in ferrets is favourably altered by treatment with the double-stranded RNA interferon inducer BRL 5907 and by the virus inhibitor Ribavirin. We also hope to show that measurement of nasal airway resistance in ferrets provides a useful additional method for evaluating antiviral compounds.
KeywordsInfluenza Virus Influenza Infection Antibody Assay Antiviral Compound Nasal Resistance
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