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In Vivo Topical Activity of the Interferon Inducer BRL 5907 and Ribavirin in Ferrets Infected with Influenza Virus

  • M. R. Boyd
  • M. F. Beeson
Part of the Chemotherapy book series (CT, volume 6)

Abstract

Many workers have shown that influenza infection in ferrets provides a highly relevant model for the infection in man (1) (2). The virus is readily transmitted from infected to non-infected animals and the progress of the disease can be monitored by body temperature, virus isolation and antibody assay. In this paper, we present data to show that the course of experimental infection in ferrets is favourably altered by treatment with the double-stranded RNA interferon inducer BRL 5907 and by the virus inhibitor Ribavirin. We also hope to show that measurement of nasal airway resistance in ferrets provides a useful additional method for evaluating antiviral compounds.

Keywords

Influenza Virus Influenza Infection Antibody Assay Antiviral Compound Nasal Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Smith, W., Andrewes, C.H. and Laidlaw, P.P. A Virus Obtained from Influenza Patients. Lancet, 2, 66 (1933).CrossRefGoogle Scholar
  2. 2.
    Francis, T. and Stuart-Harris, C.H. Studies on the Nasal Histology of Epidemic Influenza Virus Infection in the Ferret. J. Exp. Med., 68, 789 (1938).PubMedCrossRefGoogle Scholar
  3. 3.
    Sharpe, T.J., Birch, Pamela J. and Planterose, D.N. Resistance to Virus Infection During the Hyporeactive State of Interferon Induction. J. Gen. Virol., 12, 331 (1971).PubMedCrossRefGoogle Scholar
  4. 4.
    Sidwell, R.W., Huffman, J.H., Khare, G.P., Allen, Lois B.., Witkowski, J.T. and Robins, R.K. Broad Spectrum Antiviral Activity of Virazole: 1-β-D-ribo-furanosyl-1,2,4-triazole-3-carboxamide. Science, 177, 705 (1972).PubMedCrossRefGoogle Scholar
  5. 5.
    Wardle, J.R. Jr., Familiar, R.G. and Haff, R.F. A Technique for Measuring Nasal Airway Resistance in Ferrets. J. Allergy, 40, 100 (1967).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • M. R. Boyd
    • 1
  • M. F. Beeson
    • 1
  1. 1.Research DivisionBeecham PharmaceuticalsBetchworth, SurreyEngland

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