The Use of Lung Weight Changes for Evaluating the Activity of Drugs Against Influenza Infections in the Mouse
The use of lung weight measurements in mice is described as a screening procedure for measuring the activity of drugs against an A2 influenza. A sub-lethal virus challenge is given by aerosol and six doses of the drug administered subcutaneously. Lung weight is maximal after eight days and is paralleled by a decrease in body weight. Lung weight is statistically related to lung score. The technique has been used to demonstrate the activity of reference compounds.
KeywordsInfluenza Infection Infection Level Uninfected Control Body Weight Change Lung Weight
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