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The Use of Lung Weight Changes for Evaluating the Activity of Drugs Against Influenza Infections in the Mouse

  • M. F. Beeson
  • M. R. Boyd
Part of the Chemotherapy book series (CT, volume 6)

Summary

The use of lung weight measurements in mice is described as a screening procedure for measuring the activity of drugs against an A2 influenza. A sub-lethal virus challenge is given by aerosol and six doses of the drug administered subcutaneously. Lung weight is maximal after eight days and is paralleled by a decrease in body weight. Lung weight is statistically related to lung score. The technique has been used to demonstrate the activity of reference compounds.

Keywords

Influenza Infection Infection Level Uninfected Control Body Weight Change Lung Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Horsfall, F.L., J. exp. Med, 70, 209–222 (1939).PubMedCrossRefGoogle Scholar
  2. 2.
    Grunert, R.R., McGahen, J.W. and Davies, W.L., Virology, 26, 262–269 (1965).PubMedCrossRefGoogle Scholar
  3. 3.
    Kaji, M. and Tani, H., Proc. 5th Int. Cong. Chemother. 2, 19–22 (1967).Google Scholar
  4. 4.
    Korotzer, T.I., Weiss, H.S. and Somerson, N.L., Fedn. Proc. 33, 2400 (1973).Google Scholar
  5. 5.
    McGahan, J.W. and Hoffmann, C.E., Proc. Soc. exp. Biol. Med. 129, 678–681 (1968).Google Scholar
  6. 6.
    Gordon, P. and Brown, E.R., Canad. J. Microbiol. 18, 1463–1470 (1972).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • M. F. Beeson
    • 1
  • M. R. Boyd
    • 1
  1. 1.Research DivisionBeecham PharmaceuticalsBetchworth, SurreyEngland

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