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Bichlorinated Pyrimidines as Possible Antiviral Agents

  • P. La Colla
  • M. A. Marcialis
  • O. Flore
  • A. Firinu
  • A. Garzia
  • B. Loddo
Part of the Chemotherapy book series (CT, volume 6)

Summary

Several dichloropyrimidines have been found able to inhibit the growth of Polio 1, Coxsackie B, Vaccinia and HSV, but not of NDV and VSV. The antiviral effect of the most active of them, 2-amino-4,6-dichloropyrimi dine (Py 11) is very probably due to impairment of structural virus proteins.

Keywords

Vaccinia Virus Newcastle Disease Virus Vesicular Stomatitis Virus Newcastle Disease Virus Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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  4. Marcialis, M.A., La Colla, P. and Loddo, B. (1972), Experimentia 2, 1117.Google Scholar
  5. Marcialis, M.A., Schivo, M.L., Atzeni, A., Garzia, A., and Loddo, B. (1973), Experientia, 29, 1559.PubMedCrossRefGoogle Scholar
  6. Marcialis, M.A., Plore, O., Firinu, A., La Colla, P., Garzia, A. and Loddo, B. (1974), Experientia, 30, 1972.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • P. La Colla
    • 1
    • 2
  • M. A. Marcialis
    • 1
    • 2
  • O. Flore
    • 1
    • 2
  • A. Firinu
    • 1
    • 2
  • A. Garzia
    • 1
    • 2
  • B. Loddo
    • 1
    • 2
  1. 1.Institute of Microbiology IIUniversity of CagliariCagliari and LodiItaly
  2. 2.Istituto Chemioterapico ItalianoLodi, Cagliari and LodiItaly

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