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The Potential of Nucleosides as Antiviral Agents

  • R. W. Sidwell
  • L. B. Allen
  • J. H. Huffman
  • J. T. Witkowski
  • P. D. Cook
  • R. L. Tolman
  • G. R. Revankar
  • L. N. Simon
  • R. K. Robins
Part of the Chemotherapy book series (CT, volume 6)

Abstract

The world has seen a marked increase in the biochemistry of nucleosides, especially beginning in the early 1950’s when we could consider the era of modern biology was introduced by the classical work of Watson and Crick (1953). This interest has been further stimulated by the discovery of a number of nucleoside antibiotics (Suhadolnik, 1970). As we view antiviral chemotherapy, the nucleosides again have played a most significant role, perhaps beginning with Igor Tamm’s demonstration in 1956 that 1-β-D-ribo-furanosyl-5,6-dichlorobenzimidazole (Fig.1) was an in vitro inhibitor of both DNA and RNA viruses (Tamm, 1956). The 196l report by Herrmann that the halogenated pyrimidine nucleosides 5-iodo-2’-deoxyuridine (IDU, Fig.2) and 5-bromo-2’-deoxyuridine inhibited the replication of DNA viruses in vitro (Herrmann, 1961) was another key milestone, since IDU particularly was later found efficacious in treating herpetic keratitis in animals (Kaufman et al, 1962) and finally in man (Kaufman, 1962; Kaufman et al, 1962). We have since seen the advent of a multitude of nucleosides having great antiviral potential.

Keywords

Antiviral Agent Purine Nucleoside Purine Nucleoside Phosphorylase Herpetic Keratitis Cyclic Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • R. W. Sidwell
    • 1
  • L. B. Allen
    • 1
  • J. H. Huffman
    • 1
  • J. T. Witkowski
    • 1
  • P. D. Cook
    • 1
  • R. L. Tolman
    • 1
  • G. R. Revankar
    • 1
  • L. N. Simon
    • 1
  • R. K. Robins
    • 1
  1. 1.ICN Pharmaceuticals Inc.Nucleic Acid Research InstituteIrvineUSA

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