Advertisement

I.C.I. 73602 — A Potent Anti-Rhinovirus Compound

  • D. L. Swallow
  • R. A. Bucknall
  • W. E. Stanier
  • Miss A. Hutchinson
  • H. Gaskin
Part of the Chemotherapy book series (CT, volume 6)

Abstract

Guanidine has been known for a long time as a selective inhibitor of replication of small RNA viruses in tissue culture.1 The biochemical basis for this activity was traced to an inhibition of the synthesis of viral RNA polymerase,2 and thus was specific for viral replication, leaving cellular replication and function unaffected. The antiviral activity of guanidine cannot however be demonstrated in vivo, consequently much work has been carried out to try to find useful antiviral activity in derivatives of guanidine.

Keywords

Antiviral Activity Guanidine Hydrochloride Virus Yield Therapeutic Ratio Cellular Replication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    I. Tamm, and H.J. Eggers, Science, 1963, 142, 24.PubMedCrossRefGoogle Scholar
  2. 2.
    D. Baltimore, H.J. Eggers, R.M. Franklin and I. Tamm, Proc.Nat.Acad.Sci., 1963, 49, 843.PubMedCrossRefGoogle Scholar
  3. 3.
    R.A. Bucknall, D.L. Swallow, H. Moores, J. Harrad, Nature, 1973, 246, 144.CrossRefGoogle Scholar
  4. 4.
    U.K. Patent No. 1,311,432.Google Scholar
  5. 5.
    R.A. Bucknall, J. gen.Virol, 1967, 1, 55.CrossRefGoogle Scholar
  6. 6.
    R.A. Bucknall in “Advances in Pharmacology and Chemotherapy”, Academic Press, New York, p. 295, 1973.Google Scholar
  7. 7.
    N. Ledinko, Virology, 1968, 35, 584.CrossRefGoogle Scholar
  8. 8.
    R.A. Bucknall (unpublished results).Google Scholar
  9. 9.
    S. Koliais and N. Dimmock (unpublished results).Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • D. L. Swallow
    • 1
  • R. A. Bucknall
    • 1
  • W. E. Stanier
    • 1
  • Miss A. Hutchinson
    • 1
  • H. Gaskin
    • 1
  1. 1.Pharmaceuticals DivisionImperial Chemical Industries Ltd.Macclesfield, CheshireEngland

Personalised recommendations