Virus Specified Enzymes in Herpes Simplex Virus Infected Cells
The genome of Herpes simplex virus (HSV) is a molecule of double-stranded DNA with molecular weight of about 100 × 10 and consequently the polypeptide-specifying potential of herpesviruses is considerable. Although over fifty polypeptides — induced following herpes virus infection of cells in tissue culture — have been recognised, the function of most of them is still unclear, but in a few cases induced enzyme activities have been identified and studied. The present discussion is concerned chiefly with the possible role of these enzymes in antiviral chemotherapy, and in this context only herpe s virus-induced (and coded) DNA polymerase and pyrimidine deoxynucleoside kinase activities can be related to current knowledge of antiviral reagents. However, the several other enzymes implicated as herpesvirus induced-DNA exonuclease (Morrison and Keir, 1968) ribonucleotide reductase (Cohen, 1972), dTMP kinase (Nohara and Kaplan, 1963), ATPase (Randall et al., 1972), dCMP deaminase (Keir, 1968) and protein kinase (Rubenstein et al., 1972) -may well include potential target molecules for chemotherapy.
KeywordsHerpes Simplex Virus Herpes Simplex Virus Type Herpes Virus Pyrimidine Nucleoside Phosphonoacetic Acid
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