Inhibition of Influenza Virus Replication by 2-Deoxy-2,3-Dehydro-N-Trifluoroacetylneuraminic Acid (Fana)
Myxoviruses and paramyxoviruses are unique among animal viruses by virtue of their possession of a virus-coded enzyme (neuraminidase) which Is capable of liberating free N-acetyl-neuraminic acid (NANA) from a variety of sialoprotein and sialolipid substrates. Although the precise role of neuraminidase In myxovirus replication had not been defined, numerous attempts were made over a period of more than 3 decades to inhibit Influenza virus replication by the use of neuraminidase inhibitors. A variety of compounds have been shown to Inhibit neuraminidase activity in vitro including polyanions such as congo red and trypan red, dextran sulfate etc., sulfhydryl reagents, concanavalin A, oxamic acid derivatives, and benzimidazole derivatives but neuraminidase inhibition by these compounds is either nonspecific or requires very high concentrations of inhibitor.
KeywordsInfluenza Virus Virus Yield Neuraminic Acid Sulfhydryl Reagent Viral Neuraminidase
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