Molecular biology of influenza virus replication and points of action of Inhibitors
Knowledge of the details of replication of the virus should lead to more logical approaches for the selection of virus Inhibitory compounds. The Influenza virus exists as irregularly shaped particles some 75 to 190 nm in diameter bounded by an outer lipid membrane. The two envelope proteins haemagglutinin (HA) and neuraminidase (NA) take the form of spikes covering the virus surface and attached by one end at the lipid membrane. Internally the particle contains several other components of which the two major ones are the ribonucleoprotein (HP) which is closely associated with the helical RNA genome of the virus and the matrix protein (MP) which underlies the lipid membrane and may form a matrix surrounding the ribonucleoprotein-RNA complex. The polypeptide composition of highly purified Influenza virus preparations has now been established by Polyacrylamide gel electrophoresis studies. Seven polypeptides have been identified in the virus particle with molecular weights ranging from 25,000 to 94,000 daltons.
KeywordsInfluenza Virus Neuraminic Acid Influenza Virus Replication Chemoprophylactic Agent Synthetic Nucleoside Analogue
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